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dc.contributor.author
Walton, Senta
dc.contributor.author
Mandaric, Sanja
dc.contributor.author
Oxenius, Annette
dc.date.accessioned
2019-09-04T11:07:18Z
dc.date.available
2017-06-10T20:37:55Z
dc.date.available
2019-09-04T11:07:18Z
dc.date.issued
2013-05-13
dc.identifier.issn
1664-3224
dc.identifier.other
10.3389/fimmu.2013.00105
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/70955
dc.identifier.doi
10.3929/ethz-b-000070955
dc.description.abstract
The spectrum of tasks which is fulfilled by CD4 T cells in the setting of viral infections is large, ranging from support of CD8 T cells and humoral immunity to exertion of direct antiviral effector functions. While our knowledge about the differentiation pathways, plasticity, and memory of CD4 T cell responses upon acute infections or immunizations has significantly increased during the past years, much less is still known about CD4 T cell differentiation and their beneficial or pathological functions during persistent viral infections. In this review we summarize current knowledge about the differentiation, direct or indirect antiviral effector functions, and the regulation of virus-specific CD4 T cells in the setting of persistent latent or active chronic viral infections with a particular emphasis on herpes virus infections for the former and chronic lymphocytic choriomeningitis virus infection for the latter.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Research Foundation
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject
CD4 T cells
en_US
dc.subject
Persistent viral infection
en_US
dc.subject
Effector functions
en_US
dc.subject
Differentiation
en_US
dc.subject
Regulation
en_US
dc.title
CD4 T cell responses in latent and chronic viral infections
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
Frontiers in Immunology
ethz.journal.volume
4
en_US
ethz.journal.abbreviated
Front Immunol
ethz.pages.start
105
en_US
ethz.size
18 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Interplay between immunity and persistent viral infections
en_US
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::03625 - Oxenius, Annette / Oxenius, Annette
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02520 - Institut für Mikrobiologie / Institute of Microbiology::03625 - Oxenius, Annette / Oxenius, Annette
ethz.grant.agreementno
129751
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2017-06-10T20:41:03Z
ethz.source
ECIT
ethz.identifier.importid
imp593650ec287ca37524
ethz.ecitpid
pub:112390
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-24T09:15:44Z
ethz.rosetta.lastUpdated
2019-09-04T11:07:33Z
ethz.rosetta.versionExported
true
ethz.COinS
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