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dc.contributor.author
Kypriotou, Magdalini
dc.contributor.author
Rivero, Dianelys
dc.contributor.author
Haller, Sergio
dc.contributor.author
Mariotto, Anita
dc.contributor.author
Huber, Marcel
dc.contributor.author
Acha-Orbea, Hans
dc.contributor.author
Werner, Sabine
dc.contributor.author
Hohl, Daniel
dc.date.accessioned
2019-09-04T11:16:06Z
dc.date.available
2017-06-10T21:18:03Z
dc.date.available
2019-09-04T10:48:36Z
dc.date.available
2019-09-04T11:16:06Z
dc.date.issued
2013-08-22
dc.identifier.issn
1664-3224
dc.identifier.other
10.3389/fimmu.2013.00246
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/71669
dc.identifier.doi
10.3929/ethz-b-000071669
dc.description.abstract
Activin A, a member of the TGFβ superfamily, is involved in physiological processes such as cell differentiation, tissue homeostasis, wound healing, reproduction, and in pathological conditions, such as fibrosis, cancer, and asthma. Activin enhances mast cell maturation, as well as regulatory T-cell and Langerhans cell differentiation. In this study we investigated the potential role of activin in epicutaneous sensitization with ovalbumin (OVA), notably with respect to its effect on known Th2-polarization. For this purpose, transgenic mice overexpressing activin in keratinocytes and their wild-type (WT) controls were sensitized epicutaneously with OVA. Skin biopsies were analyzed with regard to histopathological features and mRNA expression of pro-inflammatory and Th1/Th2 cytokines, and Ig levels were measured in the serum. Unexpectedly, activin overexpressing animals were protected from Th2-cytokine expression and induction of OVA-specific IgE levels compared to WT animals. On the other hand, transgenic mice were more susceptible to inflammation compared to WT littermates after tape-stripping and saline (vehicle) or OVA application, as shown by increased pro-inflammatory cytokine mRNA levels and neutrophil accumulation at the site of the treatment. We conclude that activin protects from antigen-induced cutaneous Th2-polarization through modulation of the immune response. These findings highlight the role of activin in cutaneous sensitization, allergy, and in skin homeostasis.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Frontiers Research Foundation
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject
Activin
en_US
dc.subject
Epicutaneous sensitization
en_US
dc.subject
Transgenic mice
en_US
dc.subject
Inflammation
en_US
dc.subject
Atopy
en_US
dc.title
Activin A inhibits antigen-induced allergy in murine epicutaneous sensitization
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
Frontiers in Immunology
ethz.journal.volume
4
en_US
ethz.journal.abbreviated
Front Immunol
ethz.pages.start
246
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.publication.place
Lausanne
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
ethz.date.deposited
2017-06-10T21:19:22Z
ethz.source
ECIT
ethz.identifier.importid
imp593650fc833b266618
ethz.ecitpid
pub:113567
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-19T11:28:52Z
ethz.rosetta.lastUpdated
2019-09-04T11:16:27Z
ethz.rosetta.versionExported
true
ethz.COinS
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