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dc.contributor.author
Dieterich, Lothar C.
dc.contributor.author
Seidel, Catharina D.
dc.contributor.author
Detmar, Michael
dc.date.accessioned
2021-05-07T09:58:00Z
dc.date.available
2017-06-10T23:28:31Z
dc.date.available
2021-05-07T09:58:00Z
dc.date.issued
2014-04
dc.identifier.other
10.1007/s10456-013-9406-1
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/74032
dc.identifier.doi
10.3929/ethz-b-000074032
dc.description.abstract
The lymphatic system plays an important role in the physiological control of the tissue fluid balance and in the initiation of immune responses. Recent studies have shown that lymphangiogenesis, the growth of new lymphatic vessels and/or the expansion of existing lymphatic vessels, is a characteristic feature of acute inflammatory reactions and of chronic inflammatory diseases. In these conditions, lymphatic vessel expansion occurs at the tissue level but also within the draining lymph nodes. Surprisingly, activation of lymphatic vessel function by delivery of vascular endothelial growth factor-C exerts anti-inflammatory effects in several models of cutaneous and joint inflammation. These effects are likely mediated by enhanced drainage of extravasated fluid and inflammatory cells, but also by lymphatic vessel-mediated modulation of immune responses. Although some of the underlying mechanisms are just beginning to be identified, lymphatic vessels have emerged as important targets for the development of new therapeutic strategies to treat inflammatory conditions. In this context, it is of great interest that some of the currently used anti-inflammatory drugs also potently activate lymphatic vessels.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.subject
Lymphangiogenesis
en_US
dc.subject
Inflammation
en_US
dc.subject
Psoriasis
en_US
dc.subject
Arthritis
en_US
dc.subject
Endothelial cells
en_US
dc.title
Lymphatic vessels: new targets for the treatment of inflammatory diseases
en_US
dc.type
Journal Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
ethz.journal.title
Angiogenesis
ethz.journal.volume
17
en_US
ethz.journal.issue
2
en_US
ethz.pages.start
359
en_US
ethz.pages.end
371
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.notes
It was possible to publish this article open access thanks to a Swiss National Licence with the Publisher.
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
Dordrecht
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael (emeritus) / Detmar, Michael (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03683 - Detmar, Michael (emeritus) / Detmar, Michael (emeritus)
ethz.date.deposited
2017-06-10T23:29:21Z
ethz.source
ECIT
ethz.identifier.importid
imp593651282761292912
ethz.ecitpid
pub:117136
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T15:14:36Z
ethz.rosetta.lastUpdated
2022-03-29T07:09:13Z
ethz.rosetta.versionExported
true
ethz.COinS
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