Improving the Stability and Activity of Oral Therapeutic Enzymes—Recent Advances and Perspectives

Open access
Date
2014-05Type
- Journal Article
Citations
Cited 38 times in
Web of Science
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ETH Bibliography
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Abstract
Exogenous, orally-administered enzymes are currently in clinical use or under development for the treatment of pathologies, such as celiac disease and phenylketonuria. However, the administration of therapeutic enzymes via the oral route remains challenging due to potential inactivation of these fragile macromolecular entities in the harsh environment of the gastrointestinal tract. Enzymes are particularly sensitive because both proteolysis and unfolding can lead to their inactivation. Current efforts to overcome these shortcomings involve the application of gastro-resistant delivery systems and the modification of enzyme structures by polymer conjugation or protein engineering. This perspective manuscript reviews and critically discusses recent progress in the oral delivery of therapeutic enzymes, whose substrate is localized in the gastrointestinal tract. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000074053Publication status
publishedExternal links
Journal / series
Pharmaceutical ResearchVolume
Pages / Article No.
Publisher
SpringerSubject
Celiac disease; Drug therapy; Pancreas; PEGOrganisational unit
03811 - Leroux, Jean-Christophe / Leroux, Jean-Christophe
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.More
Show all metadata
Citations
Cited 38 times in
Web of Science
Cited null times in
Scopus
ETH Bibliography
yes
Altmetrics