Show simple item record

dc.contributor.author
AbdAlla, Said
dc.contributor.author
Quitterer, Ursula
dc.date.accessioned
2017-06-11T00:38:14Z
dc.date.available
2017-06-11T00:38:14Z
dc.date.issued
2013
dc.identifier.uri
http://hdl.handle.net/20.500.11850/75314
dc.description.abstract
Extracellular senile plaques of amyloid beta (Abeta) are a pathological hallmark in brain of patients with Alzheimer`s Disease (AD). Abeta is generated by the amyloidogenic processing of the amyloid precursor protein (APP). Concomitant to Abeta load, AD brain is characterized by an increase in protein level and activity of the angiotensin-converting enzyme (ACE). ACE inhibitors are a widely used class of drugs with established benefits for patients with cardiovascular disease. However, the role of ACE and ACE inhibition in the development of Abeta plaques and the process of AD-related neurodegeneration is not clear since ACE was reported to degrade Abeta. To investigate the effect of ACE inhibition on AD-related pathomechanisms, we used Tg2576 mice with neuron-specific expression of APPSwe as AD model. From 12 months of age, substantial Abeta plaque load accumulates in the hippocampus of Tg2576 mice as a brain region, which is highly vulnerable to AD-related neurodegeneration. The effect of central ACE inhibition was studied by treatment of 12 month-old Tg2576 mice for six months with the brain penetrating ACE inhibitor captopril. At an age of 18 months, hippocampal gene expression profiling was performed of captopril-treated Tg2576 mice relative to untreated 18 month-old Tg2576 controls with high Abeta plaque load. As an additional control, we used 12 month-old Tg2576 mice with low Abeta plaque load. Whole genome microarray gene expression profiling revealed gene expression changes induced by the brain-penetrating ACE inhibitor captopril, which could reflect the neuro-regenerative potential of central ACE inhibition.
dc.language.iso
en
dc.publisher
NCBI GEO database
dc.title
Hippocampal gene expression profiling of a model of Alzheimer`s Disease upon treatment with the ACE inhibitor captopril
dc.type
Other Publication
ethz.journal.title
Gene Expression Omnibus
ethz.journal.issue
GSE46871
ethz.notes
See also http://e-citations.ethbib.ethz.ch/view/pub:118930.
ethz.publication.status
published
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03735 - Quitterer, Ursula M. / Quitterer, Ursula M.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03735 - Quitterer, Ursula M. / Quitterer, Ursula M.
ethz.date.deposited
2017-06-11T00:39:06Z
ethz.source
ECIT
ethz.identifier.importid
imp593651404306249355
ethz.ecitpid
pub:118934
ethz.eth
yes
ethz.availability
Metadata only
ethz.rosetta.installDate
2017-07-15T10:20:21Z
ethz.rosetta.lastUpdated
2018-11-02T11:35:58Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Hippocampal%20gene%20expression%20profiling%20of%20a%20model%20of%20Alzheimer%60s%20Disease%20upon%20treatment%20with%20the%20ACE%20inhibitor%20captopril&rft.jtitle=Gene%20Expression%20Omnibus&rft.date=2013&rft.issue=GSE46871&rft.au=AbdAlla,%20Said&Quitterer,%20Ursula&rft.genre=unknown&
 Search via SFX

Files in this item

FilesSizeFormatOpen in viewer

There are no files associated with this item.

Publication type

Show simple item record