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dc.contributor.author
Abd Alla, Joshua
dc.contributor.author
Quitterer, Ursula
dc.date.accessioned
2017-06-11T00:38:15Z
dc.date.available
2017-06-11T00:38:15Z
dc.date.issued
2013
dc.identifier.uri
http://hdl.handle.net/20.500.11850/75315
dc.description.abstract
The fatty acid synthase (FASN) is the major fat synthesizing enzyme. FASN is an indispensable enzyme because mice with genetic deletion of Fasn are not viable. Apart from its physiological function, previous studies indicated that FASN could also exert a pathophysiological role, in the heart, because patients with heart failure showed up-reguation of FASN. To investigate the in vivo function of FASN up-regulation in the heart, we generated mice with myocardium-specific expression of FASN under control of the alpha-MHC promoter. Two different founder lines were generated with high and low FASN over-expression. Microarray gene expression profiling of heart tissue was performed of heart tissue from transgenic mice with high and low FASN expression
dc.language.iso
en
dc.publisher
NCBI GEO database
dc.title
Microarray gene expression profiling of transgenic mice with myocardium-specific over-expression of fatty acid synthase (FASN)
dc.type
Other Publication
ethz.journal.title
Gene Expression Omnibus
ethz.journal.issue
GSE49351
ethz.notes
.
ethz.publication.status
published
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03735 - Quitterer, Ursula M. / Quitterer, Ursula M.
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03735 - Quitterer, Ursula M. / Quitterer, Ursula M.
ethz.date.deposited
2017-06-11T00:39:06Z
ethz.source
ECIT
ethz.identifier.importid
imp5936514047d0641697
ethz.ecitpid
pub:118935
ethz.eth
yes
ethz.availability
Metadata only
ethz.rosetta.installDate
2017-07-13T09:02:52Z
ethz.rosetta.lastUpdated
2018-11-02T11:35:59Z
ethz.rosetta.versionExported
true
ethz.COinS
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