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dc.contributor.author
Leeb, Martin
dc.contributor.author
Wutz, Anton
dc.date.accessioned
2019-10-02T10:02:50Z
dc.date.available
2017-06-11T00:46:10Z
dc.date.available
2019-10-02T09:34:18Z
dc.date.available
2019-10-02T10:02:50Z
dc.date.issued
2013
dc.identifier.issn
1756-8935
dc.identifier.other
10.1186/1756-8935-6-41
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/75443
dc.identifier.doi
10.3929/ethz-b-000075443
dc.description.abstract
Sequencing projects have revealed the information of many animal genomes and thereby enabled the exploration of genome evolution. Insights into how genomes have been repeatedly modified provide a basis for understanding evolutionary innovation and the ever increasing complexity of animal developmental programs. Animal genomes are diploid in most cases, suggesting that redundant information in two copies of the genome increases evolutionary fitness. Genomes are well adapted to a diploid state. Changes of ploidy can be accommodated early in development but they rarely permit successful development into adulthood. In mammals, epigenetic mechanisms including imprinting and X inactivation restrict haploid development. These restrictions are relaxed in an early phase of development suggesting that dosage regulation appears less critical. Here we review the recent literature on haploid genomes and dosage effects and try to embed recent findings in an evolutionary perspective.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/2.0/
dc.subject
Haploid cells
en_US
dc.subject
Stem cells
en_US
dc.subject
Epigenetics
en_US
dc.subject
Development
en_US
dc.subject
Tumor
en_US
dc.subject
Evolution
en_US
dc.title
Haploid genomes illustrate epigenetic constraints and gene dosage effects in mammals
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 2.0 Generic
dc.date.published
2013-12-05
ethz.journal.title
Epigenetics & Chromatin
ethz.journal.volume
6
en_US
ethz.journal.abbreviated
Epigenetics Chromatin
ethz.pages.start
41
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
005711788
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02120 - Dep. Management, Technologie und Ökon. / Dep. of Management, Technology, and Ec.::03981 - Rausch, Sebastian (ehemalig) / Rausch, Sebastian (former)
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03978 - Wutz, Anton / Wutz, Anton
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02120 - Dep. Management, Technologie und Ökon. / Dep. of Management, Technology, and Ec.::03981 - Rausch, Sebastian (ehemalig) / Rausch, Sebastian (former)
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03978 - Wutz, Anton / Wutz, Anton
ethz.date.deposited
2017-06-11T00:49:31Z
ethz.source
ECIT
ethz.identifier.importid
imp593651426ba7154235
ethz.ecitpid
pub:119082
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-14T16:39:06Z
ethz.rosetta.lastUpdated
2021-02-15T06:05:56Z
ethz.rosetta.versionExported
true
ethz.COinS
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