Show simple item record

dc.contributor.author
Nowak, Katarzyna
dc.contributor.author
Seisenbacher, Gerhard
dc.contributor.author
Hafen, Ernst
dc.contributor.author
Stocker, Hugo
dc.date.accessioned
2018-09-11T12:00:36Z
dc.date.available
2017-06-11T01:01:15Z
dc.date.available
2018-09-11T12:00:36Z
dc.date.issued
2013-07
dc.identifier.issn
2050-084X
dc.identifier.other
10.7554/eLife.00380
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/75732
dc.identifier.doi
10.3929/ethz-b-000075732
dc.description.abstract
How single cells in a mitotic tissue progressively acquire hallmarks of cancer is poorly understood. We exploited mitotic recombination in developing Drosophila imaginal tissues to analyze the behavior of cells devoid of the tumor suppressor PTEN, a negative regulator of PI3K signaling, under varying nutritional conditions. Cells lacking PTEN strongly overproliferated specifically in nutrient restricted larvae. Although the PTEN mutant cells were sensitive to starvation, they successfully competed with neighboring cells by autonomous and non-autonomous mechanisms distinct from cell competition. The overgrowth was strictly dependent on the activity of the downstream components Akt/PKB and TORC1, and a reduction in amino acid uptake by reducing the levels of the amino acid transporter Slimfast caused clones of PTEN mutant cells to collapse. Our findings demonstrate how limiting nutritional conditions impact on cells lacking the tumor suppressor PTEN to cause hyperplastic overgrowth.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
eLife Sciences Publications
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
eLife
ethz.journal.volume
2
en_US
ethz.pages.start
e00380
en_US
ethz.size
21 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
007613147
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03710 - Hafen, Ernst (emeritus) / Hafen, Ernst (emeritus)
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02538 - Institut für Molekulare Systembiologie / Institute for Molecular Systems Biology::03710 - Hafen, Ernst (emeritus) / Hafen, Ernst (emeritus)
ethz.date.deposited
2017-06-11T01:04:03Z
ethz.source
ECIT
ethz.identifier.importid
imp5936514854bab94144
ethz.ecitpid
pub:119530
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T11:37:07Z
ethz.rosetta.lastUpdated
2020-02-15T14:57:28Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Nutrient%20restriction%20enhances%20the%20proliferative%20potential%20of%20cells%20lacking%20the%20tumor%20suppressor%20PTEN%20in%20mitotic%20tissues&rft.jtitle=eLife&rft.date=2013-07&rft.volume=2&rft.spage=e00380&rft.issn=2050-084X&rft.au=Nowak,%20Katarzyna&Seisenbacher,%20Gerhard&Hafen,%20Ernst&Stocker,%20Hugo&rft.genre=article&rft_id=info:doi/10.7554/eLife.00380&
 Search print copy at ETH Library

Files in this item

Thumbnail

Publication type

Show simple item record