Aminothiazole-Featured Pirinixic Acid Derivatives As Dual 5-Lipoxygenase and Microsomal Prostaglandin E-2 Synthase-1 Inhibitors with Improved Potency and Efficiency in Vivo

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Author
Hanke, Thomas
Dehm, Friederike
Liening, Stefanie
Popella, Sven-Disederius
Maczewsky, Jonas
Pillong, Max
Kunze, Jens
Weinigel, Christina
Barz, Dagmar
Kaiser, Astrid
Wurglics, Mario
Lammerhofer, Michael
Schneider, Gisbert
Sautebin, Lidia
Schubert-Zsilavecz, Manfred
Werz, Oliver
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Date
2013-10
Type
    Journal Article
Publication status
published
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Journal / series
Journal of Medicinal Chemistry
Volume
56(22)
Pages / Article No.
9031 - 9044
Publisher
American Chemical Society
Subject
molecular pharmacology; antiinflammatory drugs; product synthesis; c2-like domain; enzyme; identification; inflammation; target; sites
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Citations
Cited 54 times in Web of Science
ETH Bibliography
yes
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