- Journal Article
Rights / licenseIn Copyright - Non-Commercial Use Permitted
Lymphatic vessels have traditionally been regarded as a rather inert drainage system, which just passively transports fluids, leukocytes and antigen. However, it is becoming increasingly clear that the lymphatic vasculature is highly dynamic and plays a much more active role in inflammatory and immune processes. Tissue inflammation induces a rapid, stimulus-specific upregulation of chemokines and adhesion molecules in lymphatic endothelial cells and a proliferative expansion of the lymphatic network in the inflamed tissue and in draining lymph nodes. Moreover, increasing evidence suggests that inflammation-induced changes in the lymphatic vasculature have a profound impact on the course of inflammatory and immune responses, by modulating fluid drainage, leukocyte migration or the removal of inflammatory mediators from tissues. In this review we will summarize and discuss current knowledge of the inflammatory response of lymphatic endothelium and of inflammation-induced lymphangiogenesis and the current perspective on the overall functional significance of these processes. Show more
Journal / seriesAngiogenesis
Pages / Article No.
SubjectInflammation; Lymphatic endothelial cells; Lyphangiogenesis; Leukocyte migration; Chemokines; Drainage
Organisational unit03816 - Halin Winter, Cornelia / Halin Winter, Cornelia
138330 - Elucidating the impact of inflammation on lymphatic vessel function and on the induction of adaptive immunity (SNF)
NotesIt was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
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