
Open access
Date
2014-04Type
- Journal Article
Citations
Cited 49 times in
Web of Science
Cited 52 times in
Scopus
ETH Bibliography
yes
Altmetrics
Abstract
Lymphatic vessels have traditionally been regarded as a rather inert drainage system, which just passively transports fluids, leukocytes and antigen. However, it is becoming increasingly clear that the lymphatic vasculature is highly dynamic and plays a much more active role in inflammatory and immune processes. Tissue inflammation induces a rapid, stimulus-specific upregulation of chemokines and adhesion molecules in lymphatic endothelial cells and a proliferative expansion of the lymphatic network in the inflamed tissue and in draining lymph nodes. Moreover, increasing evidence suggests that inflammation-induced changes in the lymphatic vasculature have a profound impact on the course of inflammatory and immune responses, by modulating fluid drainage, leukocyte migration or the removal of inflammatory mediators from tissues. In this review we will summarize and discuss current knowledge of the inflammatory response of lymphatic endothelium and of inflammation-induced lymphangiogenesis and the current perspective on the overall functional significance of these processes. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000078211Publication status
publishedExternal links
Journal / series
AngiogenesisVolume
Pages / Article No.
Publisher
SpringerSubject
Inflammation; Lymphatic endothelial cells; Lyphangiogenesis; Leukocyte migration; Chemokines; DrainageOrganisational unit
03816 - Halin Winter, Cornelia / Halin Winter, Cornelia
Funding
138330 - Elucidating the impact of inflammation on lymphatic vessel function and on the induction of adaptive immunity (SNF)
Notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.More
Show all metadata
Citations
Cited 49 times in
Web of Science
Cited 52 times in
Scopus
ETH Bibliography
yes
Altmetrics