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dc.contributor.author
Lin, Tsai-Yu
dc.contributor.author
Chin, Christopher R.
dc.contributor.author
Everitt, Aaron R.
dc.contributor.author
Clare, Simon
dc.contributor.author
Perreira, Jill M.
dc.contributor.author
Savidis, George
dc.contributor.author
Aker, Aaron M.
dc.contributor.author
John, Sinu P.
dc.contributor.author
Sarlah, David
dc.contributor.author
Carreira, Erick M.
dc.contributor.author
Elledge, Stephen J.
dc.contributor.author
Kellam, Paul
dc.contributor.author
Brass, Abraham L.
dc.date.accessioned
2018-09-19T14:43:44Z
dc.date.available
2017-06-11T03:21:48Z
dc.date.available
2018-09-19T14:43:44Z
dc.date.issued
2013-11
dc.identifier.other
10.1016/j.celrep.2013.10.033
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/78523
dc.identifier.doi
10.3929/ethz-b-000078523
dc.description.abstract
The IFITMs inhibit influenza A virus (IAV) replication in vitro and in vivo. Here, we establish that the antimycotic heptaen, amphotericin B (AmphoB), prevents IFITM3-mediated restriction of IAV, thereby increasing viral replication. Consistent with its neutralization of IFITM3, a clinical preparation of AmphoB, AmBisome, reduces the majority of interferon’s protective effect against IAV in vitro. Mechanistic studies reveal that IFITM1 decreases host-membrane fluidity, suggesting both a possible mechanism for IFITM-mediated restriction and its negation by AmphoB. Notably, we reveal that mice treated with AmBisome succumbed to a normally mild IAV infection, similar to animals deficient in Ifitm3. Therefore, patients receiving antifungal therapy with clinical preparations of AmphoB may be functionally immunocompromised and thus more vulnerable to influenza, as well as other IFITM3-restricted viral infections.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.title
Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
dc.date.published
2013-11-21
ethz.journal.title
Cell Reports
ethz.journal.volume
5
en_US
ethz.journal.issue
4
en_US
ethz.pages.start
895
en_US
ethz.pages.end
908
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
007612702
ethz.publication.place
New York, NY
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03511 - Carreira, Erick M. / Carreira, Erick M.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03511 - Carreira, Erick M. / Carreira, Erick M.
ethz.date.deposited
2017-06-11T03:23:23Z
ethz.source
ECIT
ethz.identifier.importid
imp5936517da479a53846
ethz.ecitpid
pub:123535
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-17T07:44:09Z
ethz.rosetta.lastUpdated
2018-11-08T02:33:37Z
ethz.rosetta.versionExported
true
ethz.COinS
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