Show simple item record

dc.contributor.author
Meščić, Andrijana
dc.contributor.author
Betzel, Thomas
dc.contributor.author
Müller, Adrienne
dc.contributor.author
Slavik, Roger
dc.contributor.author
Čermak, Stjepko
dc.contributor.author
Raić-Malić, Silvana
dc.contributor.author
Ametamey, Simon M.
dc.date.accessioned
2019-06-27T14:20:11Z
dc.date.available
2017-06-11T03:28:24Z
dc.date.available
2019-06-27T14:20:11Z
dc.date.issued
2013-07-19
dc.identifier.issn
1420-3049
dc.identifier.other
10.3390/molecules18078535
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/78655
dc.identifier.doi
10.3929/ethz-b-000078655
dc.description.abstract
With the idea of finding a more selective radiotracer for imaging herpes simplex virus type 1 thymidine kinase (HSV1-tk) gene expression by means of positron emission tomography (PET), a novel [18F]fluorine radiolabeled pyrimidine with 4-hydroxy-3-(hydroxymethyl)butyl side chain at N-1 (HHB-5-[18F]FEP) was prepared and evaluated as a potential PET probe. Unlabeled reference compound, HHB-5-FEP, was synthesized via a five-step reaction sequence starting from 5-(2-acetoxyethyl)-4-methoxypyrimidin-2-one. The radiosynthesis of HHB-[18F]-FEP was accomplished by nucleophilic radiofluorination of a tosylate precursor using [18F]fluoride-cryptate complex in 45% ± 4 (n = 4) radiochemical yields and high purity (>99%). The biological evaluation indicated the feasibility of using HHB-5-[18F]FEP as a PET radiotracer for monitoring HSV1-tk expression in vivo.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
MDPI
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.subject
Acyclic pyrimidine nucleoside analogues
en_US
dc.subject
PCV-like side chain
en_US
dc.subject
Fluorination
en_US
dc.subject
Radiosynthesis
en_US
dc.subject
Positron emission tomography (PET)
en_US
dc.subject
HSV1-TK
en_US
dc.title
Synthesis and Biological Evaluation of a New Acyclic Pyrimidine Derivative as a Probe for Imaging Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
Molecules
ethz.journal.volume
18
en_US
ethz.journal.issue
7
en_US
ethz.journal.abbreviated
Molecules
ethz.pages.start
8535
en_US
ethz.pages.end
8549
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.publication.place
Basel
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02534 - Institut für Pharmazeutische Wiss. / Institute of Pharmaceutical Sciences::03688 - Schibli, Roger / Schibli, Roger
ethz.date.deposited
2017-06-11T03:28:42Z
ethz.source
ECIT
ethz.identifier.importid
imp593651800705443738
ethz.ecitpid
pub:123702
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T06:44:47Z
ethz.rosetta.lastUpdated
2024-02-02T08:23:41Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Synthesis%20and%20Biological%20Evaluation%20of%20a%20New%20Acyclic%20Pyrimidine%20Derivative%20as%20a%20Probe%20for%20Imaging%20Herpes%20Simplex%20Virus%20Type%201%20Thy&rft.jtitle=Molecules&rft.date=2013-07-19&rft.volume=18&rft.issue=7&rft.spage=8535&rft.epage=8549&rft.issn=1420-3049&rft.au=Me%C5%A1%C4%8Di%C4%87,%20Andrijana&Betzel,%20Thomas&M%C3%BCller,%20Adrienne&Slavik,%20Roger&%C4%8Cermak,%20Stjepko&rft.genre=article&rft_id=info:doi/10.3390/molecules18078535&
 Search print copy at ETH Library

Files in this item

Thumbnail

Publication type

Show simple item record