
Open access
Date
2013-09-01Type
- Review Article
ETH Bibliography
yes
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Abstract
Many organs of higher organisms are heavily branched structures and arise by an apparently similar process of branching morphogenesis. Yet the regulatory components and local interactions that have been identified differ greatly in these organs. It is an open question whether the regulatory processes work according to a common principle and how far physical and geometrical constraints determine the branching process. Here, we review the known regulatory factors and physical constraints in lung, kidney, pancreas, prostate, mammary gland and salivary gland branching morphogenesis, and describe the models that have been formulated to analyse their impacts. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000078696Publication status
publishedExternal links
Journal / series
Open BiologyVolume
Pages / Article No.
Publisher
Royal SocietySubject
Branching; Computational modelling; In silico organogenesisOrganisational unit
03791 - Iber, Dagmar / Iber, Dagmar
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ETH Bibliography
yes
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