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dc.contributor.author
Brühl, Annette B.
dc.contributor.author
Scherpiet, Sigrid
dc.contributor.author
Sulzer, James
dc.contributor.author
Stämpfli, Philipp
dc.contributor.author
Seifritz, Erich
dc.contributor.author
Herwig, Uwe
dc.date.accessioned
2021-05-05T15:30:29Z
dc.date.available
2017-06-11T04:46:20Z
dc.date.available
2021-05-05T15:30:29Z
dc.date.issued
2014-01
dc.identifier.issn
0896-0267
dc.identifier.issn
1573-6792
dc.identifier.other
10.1007/s10548-013-0331-9
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/80343
dc.identifier.doi
10.3929/ethz-b-000080343
dc.description.abstract
The amygdala is a central target of emotion regulation. It is overactive and dysregulated in affective and anxiety disorders and amygdala activity normalizes with successful therapy of the symptoms. However, a considerable percentage of patients do not reach remission within acceptable duration of treatment. The amygdala could therefore represent a promising target for real-time functional magnetic resonance imaging (rtfMRI) neurofeedback. rtfMRI neurofeedback directly improves the voluntary regulation of localized brain activity. At present, most rtfMRI neurofeedback studies have trained participants to increase activity of a target, i.e. up-regulation. However, in the case of the amygdala, down-regulation is supposedly more clinically relevant. Therefore, we developed a task that trained participants to down-regulate activity of the right amygdala while being confronted with amygdala stimulation, i.e. negative emotional faces. The activity in the functionally-defined region was used as online visual feedback in six healthy subjects instructed to minimize this signal using reality checking as emotion regulation strategy. Over a period of four training sessions, participants significantly increased down-regulation of the right amygdala compared to a passive viewing condition to control for habilitation effects. This result supports the concept of using rtfMRI neurofeedback training to control brain activity during relevant stimulation, specifically in the case of emotion, and has implications towards clinical treatment of emotional disorders.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Real-time fMRI
en_US
dc.subject
Neurofeedback
en_US
dc.subject
Amygdala
en_US
dc.subject
MPFC
en_US
dc.subject
Emotion regulation
en_US
dc.subject
Affective disorders
en_US
dc.subject
Anxiety
en_US
dc.subject
Faces
en_US
dc.title
Real-time Neurofeedback Using Functional MRI Could Improve Down-Regulation of Amygdala Activity During Emotional Stimulation: A Proof-of-Concept Study
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2013-11-16
ethz.journal.title
Brain Topography
ethz.journal.volume
27
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Brain Topogr
ethz.pages.start
138
en_US
ethz.pages.end
148
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
000514826
ethz.publication.place
New York
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::03827 - Gassert, Roger / Gassert, Roger
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::03827 - Gassert, Roger / Gassert, Roger
ethz.date.deposited
2017-06-11T04:50:40Z
ethz.source
ECIT
ethz.identifier.importid
imp5936519c220e350102
ethz.ecitpid
pub:126062
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T09:16:35Z
ethz.rosetta.lastUpdated
2020-02-14T13:14:44Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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