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dc.contributor.author
Richter, Kirsten
dc.contributor.author
Perriard, Guillaume
dc.contributor.author
Behrendt, Rayk
dc.contributor.author
Schwendener, Reto A.
dc.contributor.author
Sexl, Veronika
dc.contributor.author
Dunn, Robert R.
dc.contributor.author
Kamanaka, Masahito
dc.contributor.author
Flavell, Richard A.
dc.contributor.author
Roers, Axel
dc.contributor.author
Oxenius, Annette
dc.date.accessioned
2018-11-27T11:54:37Z
dc.date.available
2017-06-11T05:14:35Z
dc.date.available
2018-11-06T15:48:19Z
dc.date.available
2018-11-27T11:54:37Z
dc.date.issued
2013-11-07
dc.identifier.other
10.1371/journal.ppat.1003735
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/80796
dc.identifier.doi
10.3929/ethz-b-000080796
dc.description.abstract
Chronic viral infections lead to CD8+ T cell exhaustion, characterized by impaired cytokine secretion. Presence of the immune-regulatory cytokine IL-10 promotes chronicity of Lymphocytic Choriomeningitis Virus (LCMV) Clone 13 infection, while absence of IL-10/IL-10R signaling early during infection results in viral clearance and higher percentages and numbers of antiviral, cytokine producing T cells. IL-10 is produced by several cell types during LCMV infection but it is currently unclear which cellular sources are responsible for induction of viral chronicity. Here, we demonstrate that although dendritic cells produce IL-10 and overall IL-10 mRNA levels decrease significantly in absence of CD11c+ cells, absence of IL-10 produced by CD11c+ cells failed to improve the LCMV-specific T cell response and control of LCMV infection. Similarly, NK cell specific IL-10 deficiency had no positive impact on the LCMV-specific T cell response or viral control, even though high percentages of NK cells produced IL-10 at early time points after infection. Interestingly, we found markedly improved T cell responses and clearance of normally chronic LCMV Clone 13 infection when either myeloid cells or T cells lacked IL-10 production and mice depleted of monocytes/macrophages or CD4+ T cells exhibited reduced overall levels of IL-10 mRNA. These data suggest that the decision whether LCMV infection becomes chronic or can be cleared critically depends on early CD4+ T cell and monocyte/macrophage produced IL-10.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science (PLoS)
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Macrophage and T Cell Produced IL-10 Promotes Viral Chronicity
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
PLoS pathogens
ethz.journal.volume
9
en_US
ethz.journal.issue
11
en_US
ethz.pages.start
e1003735
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Interplay between immunity and persistent viral infections
en_US
ethz.grant
Regulation of adaptive immunity during acute and persistent viral infections
en_US
ethz.identifier.wos
ethz.identifier.nebis
005409548
ethz.publication.place
Lawrence, KS
en_US
ethz.publication.status
published
en_US
ethz.grant.agreementno
129751
ethz.grant.agreementno
146140
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.grant.program
Projektförderung in Biologie und Medizin (Abteilung III)
ethz.date.deposited
2017-06-11T05:15:36Z
ethz.source
ECIT
ethz.identifier.importid
imp593651a61259856312
ethz.ecitpid
pub:126920
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T13:55:08Z
ethz.rosetta.lastUpdated
2020-02-15T16:04:49Z
ethz.rosetta.versionExported
true
ethz.COinS
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