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dc.contributor.author
Minten, Megan A.
dc.contributor.author
Bilby, Todd R.
dc.contributor.author
Bruno, Ralph G.S.
dc.contributor.author
Allen, Carolyn C.
dc.contributor.author
Madsen, Crystal A.
dc.contributor.author
Wang, Zeping
dc.contributor.author
Sawyer, Jason E.
dc.contributor.author
Tibary, Ahmed
dc.contributor.author
Neibergs, Holly L.
dc.contributor.author
Geary, Thomas W.
dc.contributor.author
Bauersachs, Stefan
dc.contributor.author
Spencer, Thomas E.
dc.date.accessioned
2018-08-16T09:17:02Z
dc.date.available
2017-06-11T06:31:14Z
dc.date.available
2018-08-16T09:17:02Z
dc.date.issued
2013-08-05
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0069444
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/82028
dc.identifier.doi
10.3929/ethz-b-000082028
dc.description.abstract
Infertility and subfertility are important and pervasive reproductive problems in both domestic animals and humans. The majority of embryonic loss occurs during the first three weeks of pregnancy in cattle and women due, in part, to inadequate endometrial receptivity for support of embryo implantation. To identify heifers of contrasting fertility, serial rounds of artificial insemination (AI) were conducted in 201 synchronized crossbred beef heifers. The heifers were then fertility classified based on number of pregnancies detected on day 35 in four AI opportunities. Heifers, classified as having high fertility, subfertility or infertility, were selected for further study. The fertility-classified heifers were superovulated and flushed, and the recovered embryos were graded and then transferred to synchronized recipients. Quantity of embryos recovered per flush, embryo quality, and subsequent recipient pregnancy rates did not differ by fertility classification. Two in vivo-produced bovine embryos (stage 4 or 5, grade 1 or 2) were then transferred into each heifer on day 7 post-estrus. Pregnancy rates were greater in high fertility than lower fertility heifers when heifers were used as embryo recipients. The reproductive tracts of the classified heifers were obtained on day 14 of the estrous cycle. No obvious morphological differences in reproductive tract structures and histology of the uterus were observed in the heifers. Microarray analysis revealed differences in the endometrial transcriptome based on fertility classification. A genome-wide association study, based on SNP genotyping, detected 7 moderate associations with fertility across 6 different chromosomes. Collectively, these studies support the idea that innate differences in uterine function underlie fertility and early pregnancy loss in ruminants. Cattle with defined early pregnancy success or loss is useful to elucidate the complex biological and genetic mechanisms governing endometrial receptivity and uterine competency for pregnancy.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/publicdomain/zero/1.0/
dc.title
Effects of fertility on gene expression and function of the bovine endometrium
en_US
dc.type
Journal Article
dc.rights.license
CC0 1.0 Universal
ethz.journal.title
PLoS ONE
ethz.journal.volume
8
en_US
ethz.journal.issue
8
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e69444
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.nebis
006206116
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02703 - Institut für Agrarwissenschaften / Institute of Agricultural Sciences::03999 - Ulbrich, Susanne / Ulbrich, Susanne
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02703 - Institut für Agrarwissenschaften / Institute of Agricultural Sciences::03999 - Ulbrich, Susanne / Ulbrich, Susanne
ethz.date.deposited
2017-06-11T06:33:14Z
ethz.source
ECIT
ethz.identifier.importid
imp593651bff058272872
ethz.ecitpid
pub:129259
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T16:44:43Z
ethz.rosetta.lastUpdated
2018-11-07T23:25:12Z
ethz.rosetta.versionExported
true
ethz.COinS
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