Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity

Open access
Date
2014-04Type
- Journal Article
Citations
Cited 27 times in
Web of Science
Cited 27 times in
Scopus
ETH Bibliography
yes
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Abstract
Patients with Parkinson’s disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70 % reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily. Show more
Permanent link
https://doi.org/10.3929/ethz-b-000082695Publication status
publishedExternal links
Journal / series
Journal of Neural TransmissionVolume
Pages / Article No.
Publisher
SpringerSubject
Parkinson's disease; MAO-A; MAO-B inhibitors; Selegiline; RasagilineNotes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.More
Show all metadata
Citations
Cited 27 times in
Web of Science
Cited 27 times in
Scopus
ETH Bibliography
yes
Altmetrics