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dc.contributor.author
Bartl, Jasmin
dc.contributor.author
Müller, Thomas
dc.contributor.author
Grünblatt, Edna
dc.contributor.author
Gerlach, Manfred
dc.contributor.author
Riederer, Peter
dc.date.accessioned
2021-05-05T14:36:49Z
dc.date.available
2017-06-11T07:08:28Z
dc.date.available
2021-05-05T14:36:49Z
dc.date.issued
2014-04
dc.identifier.issn
1435-1463
dc.identifier.issn
0300-9564
dc.identifier.other
10.1007/s00702-013-1120-z
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/82695
dc.identifier.doi
10.3929/ethz-b-000082695
dc.description.abstract
Patients with Parkinson’s disease receive selective irreversible monoamine oxidase (MAO)-B inhibitors, but their effects on MAO-A activity are not known during long-term application. We determined MAO-A inhibition in plasma samples from patients with MAO-B inhibitor intake or without MAO-B inhibitor treatment and from healthy controls. We detected a 70 % reduction of MAO-A activity in patients with MAO-B inhibitor therapy in comparison to the other groups. Our results suggest that treatment with MAO-B inhibitor may also influence MAO-A activity in vivo, when administered daily.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Springer
en_US
dc.rights.uri
http://rightsstatements.org/page/InC-NC/1.0/
dc.subject
Parkinson's disease
en_US
dc.subject
MAO-A
en_US
dc.subject
MAO-B inhibitors
en_US
dc.subject
Selegiline
en_US
dc.subject
Rasagiline
en_US
dc.title
Chronic monoamine oxidase-B inhibitor treatment blocks monoamine oxidase-A enzyme activity
en_US
dc.type
Journal Article
dc.rights.license
In Copyright - Non-Commercial Use Permitted
dc.date.published
2013-11-23
ethz.journal.title
Journal of Neural Transmission
ethz.journal.volume
121
en_US
ethz.journal.issue
4
en_US
ethz.journal.abbreviated
J Neural Transm
ethz.pages.start
379
en_US
ethz.pages.end
383
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher.
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
000049433
ethz.publication.place
Wien
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T07:11:10Z
ethz.source
ECIT
ethz.identifier.importid
imp593651ca45e2e47460
ethz.ecitpid
pub:130454
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T17:51:34Z
ethz.rosetta.lastUpdated
2018-08-02T14:04:52Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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