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dc.contributor.author
von der Behrens, Wolfger
dc.date.accessioned
2019-11-08T13:13:59Z
dc.date.available
2017-06-11T07:57:49Z
dc.date.available
2019-11-08T13:13:59Z
dc.date.issued
2014
dc.identifier.issn
2090-5904
dc.identifier.issn
1687-5443
dc.identifier.other
10.1155/2014/741452
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/83636
dc.identifier.doi
10.3929/ethz-b-000083636
dc.description.abstract
Tinnitus is one of the major audiological diseases, affecting a significant portion of the ageing society. Despite its huge personal and presumed economic impact there are only limited therapeutic options available. The reason for this deficiency lies in the very nature of the disease as it is deeply connected to elementary plasticity of auditory processing in the central nervous system. Understanding these mechanisms is essential for developing a therapy that reverses the plastic changes underlying the pathogenesis of tinnitus. This requires experiments that address individual neurons and small networks, something usually not feasible in human patients. However, in animals such invasive experiments on the level of single neurons with high spatial and temporal resolution are possible. Therefore, animal models are a very critical element in the combined efforts for engineering new therapies. This review provides an overview over the most important features of animal models of tinnitus: which laboratory species are suitable, how to induce tinnitus, and how to characterize the perceived tinnitus by behavioral means. In particular, these aspects of tinnitus animal models are discussed in the light of transferability to the human patients.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Hindawi
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Animal Models of Subjective Tinnitus
en_US
dc.type
Review Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
ethz.journal.title
Neural Plasticity
ethz.journal.volume
2014
en_US
ethz.pages.start
741452
en_US
ethz.size
13 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
010196736
ethz.publication.place
Cairo
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T07:58:53Z
ethz.source
ECIT
ethz.identifier.importid
imp593651dc4838c53366
ethz.ecitpid
pub:131969
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-25T18:41:13Z
ethz.rosetta.lastUpdated
2020-02-15T22:26:27Z
ethz.rosetta.versionExported
true
ethz.COinS
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