Show simple item record

dc.contributor.author
Huang, X.G.
dc.contributor.author
Yee, B.K.
dc.contributor.author
Nag, S.
dc.contributor.author
Chan, S.T.H.
dc.contributor.author
Tang, F.
dc.date.accessioned
2023-10-24T06:44:48Z
dc.date.available
2017-06-11T08:45:39Z
dc.date.available
2023-10-24T06:44:48Z
dc.date.issued
2003-10
dc.identifier.issn
0014-4886
dc.identifier.issn
1090-2430
dc.identifier.other
10.1016/S0014-4886(03)00242-5
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/84405
dc.description.abstract
Human presenilin-1 (PS1) mutations are associated with the incidence of familial Alzheimer’s disease. The present study evaluated the behavioral and neurochemical effects of the L235P mutation (substitution of leucine by proline at codon 235) of the human PS1 gene, which has been linked to a form of early-onset Alzheimer’s disease. Except for a significant increase in the production of β-amyloid-42, the mutant mice did not show any overt signs of Alzheimer-like neuropathology in the form of plaque formation, changes in choline acetyltransferase activity, or somatostatin content in the brain. Cognitive assays indicated that the mutation did not affect the acquisition or reversal of a spatial reference memory task in the water maze or performance on a spatial working memory task. In contrast, L235P PS1 transgenic mice exhibited a significant impairment in a test of spontaneous object recognition. This dissociation is suggestive of a preferential impairment of the extrahippocampal memory system and is consistent with what has been reported in another pathological mutation (substitution of leucine by valine at codon 286) of the PS1 gene.
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.subject
Alzheimer’s disease
en_US
dc.subject
β-Amyloid
en_US
dc.subject
Choline acetyltransferase
en_US
dc.subject
Object recognition memory
en_US
dc.subject
Presenilin-1
en_US
dc.subject
Somatostatin
en_US
dc.subject
Water maze
en_US
dc.title
Behavioral and neurochemical characterization of transgenic mice carrying the human presenilin-1 gene with or without the leucine-to-proline mutation at codon 235
en_US
dc.type
Journal Article
dc.date.published
2003-08-23
ethz.journal.title
Experimental Neurology
ethz.journal.volume
183
en_US
ethz.journal.issue
2
en_US
ethz.journal.abbreviated
Exp Neurol
ethz.pages.start
673
en_US
ethz.pages.end
681
en_US
ethz.publication.place
San Diego, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
03418 - Feldon, Joram
en_US
ethz.leitzahl.certified
03418 - Feldon, Joram
ethz.date.deposited
2017-06-11T08:46:40Z
ethz.source
ECIT
ethz.identifier.importid
imp593651ebca0c965123
ethz.ecitpid
pub:133194
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-26T19:59:23Z
ethz.rosetta.lastUpdated
2024-02-03T05:39:56Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Behavioral%20and%20neurochemical%20characterization%20of%20transgenic%20mice%20carrying%20the%20human%20presenilin-1%20gene%20with%20or%20without%20the%20leucine-to-prol&rft.jtitle=Experimental%20Neurology&rft.date=2003-10&rft.volume=183&rft.issue=2&rft.spage=673&rft.epage=681&rft.issn=0014-4886&1090-2430&rft.au=Huang,%20X.G.&Yee,%20B.K.&Nag,%20S.&Chan,%20S.T.H.&Tang,%20F.&rft.genre=article&rft_id=info:doi/10.1016/S0014-4886(03)00242-5&
 Search print copy at ETH Library

Files in this item

FilesSizeFormatOpen in viewer

There are no files associated with this item.

Publication type

Show simple item record