Zur Kurzanzeige

dc.contributor.author
Moradigaravand, Danesh
dc.contributor.author
Engelstädter, Jan
dc.date.accessioned
2018-05-16T16:44:54Z
dc.date.available
2017-06-11T11:03:02Z
dc.date.available
2018-05-16T16:44:54Z
dc.date.issued
2014-06
dc.identifier.issn
1471-2148
dc.identifier.other
10.1186/1471-2148-14-141
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/86787
dc.identifier.doi
10.3929/ethz-b-000086787
dc.description.abstract
Background Recent studies have demonstrated that natural transformation and the formation of highly structured populations in bacteria are interconnected. In spite of growing evidence about this connection, little is known about the dynamics of natural transformation in spatially structured bacterial populations. Results In this work, we model the interdependency between the dynamics of the bacterial gene pool and those of environmental DNA in space to dissect the effect of transformation on adaptation. Our model reveals that even with only a single locus under consideration, transformation with a free DNA fragment pool results in complex adaptation dynamics that do not emerge in previous models focusing only on the gene shuffling effect of transformation at multiple loci. We demonstrate how spatial restriction on population growth and DNA diffusion in the environment affect the impact of transformation on adaptation. We found that in structured bacterial populations intermediate DNA diffusion rates predominantly cause transformation to impede adaptation by spreading deleterious alleles in the population. Conclusion Overall, our model highlights distinctive evolutionary consequences of bacterial transformation in spatially restricted compared to planktonic bacterial populations.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Bacterial adaptation
en_US
dc.subject
Bacterial transformation
en_US
dc.subject
Biofilm
en_US
dc.subject
Spatially structured populations
en_US
dc.title
The impact of natural transformation on adaptation in spatially structured bacterial populations
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
BMC Evolutionary Biology
ethz.journal.volume
14
en_US
ethz.journal.abbreviated
BMC evol. biol.
ethz.pages.start
141
en_US
ethz.size
9p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Why do bacteria have sex? Theoretical and experimental investigations into the evolution of bacterial transformation
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ethz.grant.agreementno
132934
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Ambizione
ethz.date.deposited
2017-06-11T11:05:36Z
ethz.source
ECIT
ethz.identifier.importid
imp5936521b2318635486
ethz.ecitpid
pub:136573
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T20:10:33Z
ethz.rosetta.lastUpdated
2024-02-02T04:49:05Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=The%20impact%20of%20natural%20transformation%20on%20adaptation%20in%20spatially%20structured%20bacterial%20populations&rft.jtitle=BMC%20Evolutionary%20Biology&rft.date=2014-06&rft.volume=14&rft.spage=141&rft.issn=1471-2148&rft.au=Moradigaravand,%20Danesh&Engelst%C3%A4dter,%20Jan&rft.genre=article&rft_id=info:doi/10.1186/1471-2148-14-141&
 Printexemplar via ETH-Bibliothek suchen

Dateien zu diesem Eintrag

Thumbnail

Publikationstyp

Zur Kurzanzeige