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dc.contributor.author
Moradigaravand, Danesh
dc.contributor.author
Kouyos, Roger
dc.contributor.author
Hinkley, Trevor
dc.contributor.author
Haddad, Mojgan
dc.contributor.author
Petropoulos, Christos J.
dc.contributor.author
Engelstädter, Jan
dc.contributor.author
Bonhoeffer, Sebastian
dc.date.accessioned
2018-11-05T10:50:26Z
dc.date.available
2017-06-11T11:43:44Z
dc.date.available
2018-11-05T10:50:26Z
dc.date.issued
2014-06-26
dc.identifier.issn
1553-7390
dc.identifier.issn
1553-7404
dc.identifier.other
10.1371/journal.pgen.1004439
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/87591
dc.identifier.doi
10.3929/ethz-b-000087591
dc.description.abstract
Recombination has the potential to facilitate adaptation. In spite of the substantial body of theory on the impact of recombination on the evolutionary dynamics of adapting populations, empirical evidence to test these theories is still scarce. We examined the effect of recombination on adaptation on a large-scale empirical fitness landscape in HIV-1 based on in vitro fitness measurements. Our results indicate that recombination substantially increases the rate of adaptation under a wide range of parameter values for population size, mutation rate and recombination rate. The accelerating effect of recombination is stronger for intermediate mutation rates but increases in a monotonic way with the recombination rates and population sizes that we examined. We also found that both fitness effects of individual mutations and epistatic fitness interactions cause recombination to accelerate adaptation. The estimated epistasis in the adapting populations is significantly negative. Our results highlight the importance of recombination in the evolution of HIV-I.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science (PLoS)
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Recombination Accelerates Adaptation on a Large-Scale Empirical Fitness Landscape in HIV-1
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS Genetics
ethz.journal.volume
10
en_US
ethz.journal.issue
6
en_US
ethz.journal.abbreviated
PLoS Genet
ethz.pages.start
e1004439
en_US
ethz.size
8 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Why do bacteria have sex? Theoretical and experimental investigations into the evolution of bacterial transformation
en_US
ethz.grant
Evolutionary genetics of HIV-1: Exploring evolution on complex fitness landscapes
en_US
ethz.identifier.wos
ethz.identifier.nebis
005410305
ethz.publication.place
San Francisco, CA
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02350 - Dep. Umweltsystemwissenschaften / Dep. of Environmental Systems Science::02720 - Institut für Integrative Biologie / Institute of Integrative Biology::03584 - Bonhoeffer, Sebastian / Bonhoeffer, Sebastian
ethz.grant.agreementno
132934
ethz.grant.agreementno
133129
ethz.grant.fundername
SNF
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Ambizione
ethz.grant.program
Bonus of Excellence
ethz.date.deposited
2017-06-11T11:44:17Z
ethz.source
ECIT
ethz.identifier.importid
imp59365229a81f413812
ethz.ecitpid
pub:137812
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T03:05:43Z
ethz.rosetta.lastUpdated
2018-11-02T15:23:02Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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