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dc.contributor.author
Uddin, Mohammad N.
dc.contributor.author
Dunoyer, Patrice
dc.contributor.author
Schott, Grégory
dc.contributor.author
Akhter, Salina
dc.contributor.author
Shi, Chun-Lin
dc.contributor.author
Lucas, William J.
dc.contributor.author
Voinnet, Olivier
dc.contributor.author
Kim, Jae-Yean
dc.date.accessioned
2020-07-07T05:39:49Z
dc.date.available
2017-06-11T11:57:25Z
dc.date.available
2019-04-04T11:01:09Z
dc.date.available
2020-07-07T05:39:49Z
dc.date.issued
2014-07-08
dc.identifier.issn
1362-4962
dc.identifier.issn
0301-5610
dc.identifier.other
10.1093/nar/gku422
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/88140
dc.identifier.doi
10.3929/ethz-b-000088140
dc.description.abstract
RNA silencing is an evolutionarily conserved mechanism triggered by double-stranded RNA that is processed into 21- to 24-nt small interfering (si)RNA or micro (mi)RNA by RNaseIII-like enzymes called Dicers. Gene regulations by RNA silencing have fundamental implications in a large number of biological processes that include antiviral defense, maintenance of genome integrity and the orchestration of cell fates. Although most generic or core components of the various plant small RNA pathways have been likely identified over the past 15 years, factors involved in RNAi regulation through post-translational modifications are just starting to emerge, mostly through forward genetic studies. A genetic screen designed to identify factors required for RNAi in Arabidopsis identified the serine/threonine protein kinase, TOUSLED (TSL). Mutations in TSL affect exogenous and virus-derived siRNA activity in a manner dependent upon its kinase activity. By contrast, despite their pleiotropic developmental phenotype, tsl mutants show no defect in biogenesis or activity of miRNA or endogenous trans-acting siRNA. These data suggest a possible role for TSL phosphorylation in the specific regulation of exogenous and antiviral RNA silencing in Arabidopsis and identify TSL as an intrinsic regulator of RNA interference.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Oxford University Press
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
The protein kinase TOUSLED facilitates RNAi in Arabidopsis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2014-06-11
ethz.journal.title
Nucleic Acids Research
ethz.journal.volume
42
en_US
ethz.journal.issue
12
en_US
ethz.journal.abbreviated
Nucleic Acids Res.
ethz.pages.start
7971
en_US
ethz.pages.end
7980
en_US
ethz.size
10 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.notes
It was possible to publish this article open access thanks to a Swiss National Licence with the publisher
en_US
ethz.identifier.wos
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02541 - Institut für Molekulare Pflanzenbiologie / Institute of Molecular Plant Biology::03876 - Voinnet, Olivier / Voinnet, Olivier
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02541 - Institut für Molekulare Pflanzenbiologie / Institute of Molecular Plant Biology::03876 - Voinnet, Olivier / Voinnet, Olivier
ethz.date.deposited
2017-06-11T11:57:45Z
ethz.source
ECIT
ethz.identifier.importid
imp593652358ab0555686
ethz.ecitpid
pub:138731
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-26T03:40:32Z
ethz.rosetta.lastUpdated
2024-02-02T11:21:50Z
ethz.rosetta.versionExported
true
ethz.COinS
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