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dc.contributor.author
Bopp, Rita
dc.contributor.author
da Costa, Nuno M.
dc.contributor.author
Kampa, Björn M.
dc.contributor.author
Martin, Kevan A.C.
dc.contributor.author
Roth, Morgane M.
dc.date.accessioned
2019-06-07T08:18:27Z
dc.date.available
2017-06-11T12:50:27Z
dc.date.available
2019-06-07T08:18:27Z
dc.date.issued
2014-08-19
dc.identifier.issn
1544-9173
dc.identifier.issn
1545-7885
dc.identifier.other
10.1371/journal.pbio.1001932
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/90296
dc.identifier.doi
10.3929/ethz-b-000090296
dc.description.abstract
One of the hallmarks of neocortical circuits is the predominance of recurrent excitation between pyramidal neurons, which is balanced by recurrent inhibition from smooth GABAergic neurons. It has been previously described that in layer 2/3 of primary visual cortex (V1) of cat and monkey, pyramidal cells filled with horseradish peroxidase connect approximately in proportion to the spiny (excitatory, 95% and 81%, respectively) and smooth (GABAergic, 5% and 19%, respectively) dendrites found in the neuropil. By contrast, a recent ultrastructural study of V1 in a single mouse found that smooth neurons formed 51% of the targets of the superficial layer pyramidal cells. This suggests that either the neuropil of this particular mouse V1 had a dramatically different composition to that of V1 in cat and monkey, or that smooth neurons were specifically targeted by the pyramidal cells in that mouse. We tested these hypotheses by examining similar cells filled with biocytin in a sample of five mice. We found that the average composition of the neuropil in V1 of these mice was similar to that described for cat and monkey V1, but that the superficial layer pyramidal cells do form proportionately more synapses with smooth dendrites than the equivalent neurons in cat or monkey. These distributions may underlie the distinct differences in functional architecture of V1 between rodent and higher mammals.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Pyramidal Cells Make Specific Connections onto Smooth (GABAergic) Neurons in Mouse Visual Cortex
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS Biology
ethz.journal.volume
12
en_US
ethz.journal.issue
8
en_US
ethz.journal.abbreviated
PLoS biol.
ethz.pages.start
e1001932
en_US
ethz.size
12 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.grant
Neural Circuit Reconstruction
en_US
ethz.identifier.wos
ethz.identifier.nebis
004606893
ethz.publication.place
Lawrence, KS
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich, direkt::00012 - Lehre und Forschung, direkt::00007 - Departemente, direkt::02140 - Departement Informationstechnologie und Elektrotechnik / Department of Information Technology and Electrical Engineering::02533 - Institut für Neuroinformatik (INI) / Institute of Neuroinformatics (INI)::03454 - Martin, Kevan A.C.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich, direkt::00012 - Lehre und Forschung, direkt::00007 - Departemente, direkt::02140 - Departement Informationstechnologie und Elektrotechnik / Department of Information Technology and Electrical Engineering::02533 - Institut für Neuroinformatik (INI) / Institute of Neuroinformatics (INI)::03454 - Martin, Kevan A.C.
ethz.grant.agreementno
130470
ethz.grant.fundername
SNF
ethz.grant.funderDoi
10.13039/501100001711
ethz.grant.program
Sinergia
ethz.date.deposited
2017-06-11T12:50:45Z
ethz.source
ECIT
ethz.identifier.importid
imp5936525fb434d97837
ethz.ecitpid
pub:142120
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T09:20:24Z
ethz.rosetta.lastUpdated
2019-06-07T08:18:39Z
ethz.rosetta.versionExported
true
ethz.COinS
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