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dc.contributor.author
Beer, Hans-Dietmar
dc.contributor.author
Munding, Christine
dc.contributor.author
Dubois, Nicole
dc.contributor.author
Mamie, Céline
dc.contributor.author
Hohl, Daniel
dc.contributor.author
Werner, Sabine
dc.date.accessioned
2022-11-29T09:26:13Z
dc.date.available
2017-06-11T13:24:03Z
dc.date.available
2017-12-13T11:24:43Z
dc.date.available
2022-10-12T13:00:48Z
dc.date.available
2022-11-29T09:26:13Z
dc.date.issued
2002-06
dc.identifier.issn
0021-9258
dc.identifier.issn
1083-351X
dc.identifier.other
10.1074/jbc.M111233200
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/91604
dc.identifier.doi
10.3929/ethz-b-000091604
dc.description.abstract
Keratinocyte growth factor (KGF) regulates proliferation, differentiation, migration, and survival of different types of epithelial cells, including keratinocytes of the skin. To gain insight into the mechanisms underlying these multiple functions, we searched for KGF- regulated genes in keratinocytes. Using the differential display reverse transcriptase-PCR technology, we identified the gene encoding the estrogen-responsive B box protein (EBBP) which has as yet not been functionally characterized. The full-length murine and human EBBP cDNAs were cloned and fully sequenced. They were shown to encode 75-kDa proteins, which are mainly localized in the cytoplasm of keratinocytes in vitro and in vivo. In vivo, EBBP was found at high levels in the KGF- and epidermal growth factor-responsive basal keratinocytes of human skin, but the expression was down-regulated in the hyperthickened epithelium of skin wounds. Stable overexpression of EBBP in HaCaT keratinocytes did not affect the proliferation rate of the transfected cells, but enhanced the early differentiation process. These results suggest that the presence of EBBP in basal keratinocytes is important for the differentiation capacity of these cells, and that down-regulation of EBBP expression in a hyperproliferative epithelium is required to maintain the cells in a non-differentiated stage.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
The American Society for Biochemistry and Molecular Biology
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
The estrogen-responsive B box protein - A novel regulator of keratinocyte differentiation
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
dc.date.published
2001-11-26
ethz.journal.title
Journal of Biological Chemistry
ethz.journal.volume
277
en_US
ethz.journal.issue
23
en_US
ethz.journal.abbreviated
J Biol Chem
ethz.pages.start
20740
en_US
ethz.pages.end
20749
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.nebis
000040237
ethz.publication.place
Bethesda, MD
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02030 - Dep. Biologie / Dep. of Biology::02539 - Institut für Molecular Health Sciences / Institute of Molecular Health Sciences::03520 - Werner, Sabine / Werner, Sabine
ethz.date.deposited
2017-06-11T13:24:53Z
ethz.source
ECIT
ethz.identifier.importid
imp59365277a195d80086
ethz.ecitpid
pub:143998
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T09:37:26Z
ethz.rosetta.lastUpdated
2021-02-14T21:21:23Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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