Show simple item record

dc.contributor.author
Metanis, Norman
dc.contributor.author
Hilvert, Donald
dc.date.accessioned
2019-06-06T14:41:10Z
dc.date.available
2017-06-11T14:28:42Z
dc.date.available
2019-06-06T14:41:10Z
dc.date.issued
2015-01-01
dc.identifier.issn
2041-6520
dc.identifier.issn
2041-6539
dc.identifier.other
10.1039/c4sc02379j
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/94087
dc.identifier.doi
10.3929/ethz-b-000094087
dc.description.abstract
Although oxidative folding of disulfide-rich proteins is often sluggish, this process can be significantly enhanced by targeted replacement of cysteines with selenocysteines. In this study, we examined the effects of a selenosulfide and native versus nonnative diselenides on the folding rates and mechanism of bovine pancreatic trypsin inhibitor. Our results show that such sulfur-to-selenium substitutions alter the distribution of key folding intermediates and enhance their rates of interconversion in a context-dependent manner.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Royal Society of Chemistry
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/3.0/
dc.title
Harnessing selenocysteine reactivity for oxidative protein folding
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 3.0 Unported
dc.date.published
2014-09-23
ethz.journal.title
Chemical Science
ethz.journal.volume
6
en_US
ethz.journal.issue
1
en_US
ethz.journal.abbreviated
Chem. sci.
ethz.pages.start
322
en_US
ethz.pages.end
325
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
006104946
ethz.publication.place
Cambridge
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03492 - Hilvert, Donald / Hilvert, Donald
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02020 - Dep. Chemie und Angewandte Biowiss. / Dep. of Chemistry and Applied Biosc.::02514 - Laboratorium für Organische Chemie / Laboratory of Organic Chemistry::03492 - Hilvert, Donald / Hilvert, Donald
ethz.date.deposited
2017-06-11T14:29:25Z
ethz.source
ECIT
ethz.identifier.importid
imp593652a54a9c294803
ethz.ecitpid
pub:147944
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-17T09:35:44Z
ethz.rosetta.lastUpdated
2019-06-06T14:41:19Z
ethz.rosetta.versionExported
true
ethz.COinS
ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.atitle=Harnessing%20selenocysteine%20reactivity%20for%20oxidative%20protein%20folding&rft.jtitle=Chemical%20Science&rft.date=2015-01-01&rft.volume=6&rft.issue=1&rft.spage=322&rft.epage=325&rft.issn=2041-6520&2041-6539&rft.au=Metanis,%20Norman&Hilvert,%20Donald&rft.genre=article&
 Search via SFX

Files in this item

Thumbnail

Publication type

Show simple item record