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dc.contributor.author
Calteau, Alexandra
dc.contributor.author
Fewer, David P.
dc.contributor.author
Latifi, Amel
dc.contributor.author
Coursin, Thérèse
dc.contributor.author
Laurent, Thierry
dc.contributor.author
Jokela, Jouni
dc.contributor.author
Kerfeld, Cheryl A.
dc.contributor.author
Sivonen, Kaarina
dc.contributor.author
Piel, Jörn
dc.contributor.author
Gugger, Muriel
dc.date.accessioned
2018-10-01T12:45:50Z
dc.date.available
2017-06-11T14:49:07Z
dc.date.available
2018-10-01T12:45:50Z
dc.date.issued
2014-11
dc.identifier.other
10.1186/1471-2164-15-977
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/94795
dc.identifier.doi
10.3929/ethz-b-000094795
dc.description.abstract
Background Cyanobacteria are an ancient lineage of photosynthetic bacteria from which hundreds of natural products have been described, including many notorious toxins but also potent natural products of interest to the pharmaceutical and biotechnological industries. Many of these compounds are the products of non-ribosomal peptide synthetase (NRPS) or polyketide synthase (PKS) pathways. However, current understanding of the diversification of these pathways is largely based on the chemical structure of the bioactive compounds, while the evolutionary forces driving their remarkable chemical diversity are poorly understood. Results We carried out a phylum-wide investigation of genetic diversification of the cyanobacterial NRPS and PKS pathways for the production of bioactive compounds. 452 NRPS and PKS gene clusters were identified from 89 cyanobacterial genomes, revealing a clear burst in late-branching lineages. Our genomic analysis further grouped the clusters into 286 highly diversified cluster families (CF) of pathways. Some CFs appeared vertically inherited, while others presented a more complex evolutionary history. Only a few horizontal gene transfers were evidenced amongst strongly conserved CFs in the phylum, while several others have undergone drastic gene shuffling events, which could result in the observed diversification of the pathways. Conclusions Therefore, in addition to toxin production, several NRPS and PKS gene clusters are devoted to important cellular processes of these bacteria such as nitrogen fixation and iron uptake. The majority of the biosynthetic clusters identified here have unknown end products, highlighting the power of genome mining for the discovery of new natural products.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
BioMed Central
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
Cyanobacteria
en_US
dc.subject
Secondary metabolite
en_US
dc.subject
NRPS
en_US
dc.subject
PKS
en_US
dc.subject
Diversity
en_US
dc.subject
Evolution
en_US
dc.title
Phylum-wide comparative genomics unravel the diversity of secondary metabolism in Cyanobacteria
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
BMC Genomics
ethz.journal.volume
15
en_US
ethz.pages.start
977
en_US
ethz.size
14 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.scopus
ethz.identifier.nebis
004256340
ethz.publication.place
London
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T14:49:34Z
ethz.source
ECIT
ethz.identifier.importid
imp593652b23794714230
ethz.ecitpid
pub:148893
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-18T15:42:23Z
ethz.rosetta.lastUpdated
2018-10-01T12:45:56Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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