Altered functional connectivity of the language network in ASD: Role of classical language areas and cerebellum
dc.contributor.author
Verly, Marjolein
dc.contributor.author
Verhoeven, Judith
dc.contributor.author
Zink, Inge
dc.contributor.author
Mantini, Dante
dc.contributor.author
Peeters, Ronald
dc.contributor.author
Deprez, Sabine
dc.contributor.author
Emsell, Louise
dc.contributor.author
Boets, Bart
dc.contributor.author
Noens, Ilse
dc.contributor.author
Steyaert, Jean
dc.contributor.author
Lagae, Lieven
dc.contributor.author
Cock, Paul de
dc.contributor.author
Rommel, Nathalie
dc.contributor.author
Sunaert, Stefan
dc.date.accessioned
2019-07-01T14:13:02Z
dc.date.available
2017-06-11T14:49:21Z
dc.date.available
2017-10-26T10:02:51Z
dc.date.available
2019-07-01T14:13:02Z
dc.date.issued
2014
dc.identifier.issn
2213-1582
dc.identifier.other
10.1016/j.nicl.2014.01.008
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/94822
dc.identifier.doi
10.3929/ethz-b-000094822
dc.description.abstract
The development of language, social interaction and communicative skills is remarkably different in the child with autism spectrum disorder (ASD). Atypical brain connectivity has frequently been reported in this patient population. However, the neural correlates underlying their disrupted language development and functioning are still poorly understood. Using resting state fMRI, we investigated the functional connectivity properties of the language network in a group of ASD patients with clear comorbid language impairment (ASD-LI; N = 19) and compared them to the language related connectivity properties of 23 age-matched typically developing children. A verb generation task was used to determine language components commonly active in both groups. Eight joint language components were identified and subsequently used as seeds in a resting state analysis. Interestingly, both the interregional and the seed-based whole brain connectivity analysis showed preserved connectivity between the classical intrahemispheric language centers, Wernicke's and Broca's areas. In contrast however, a marked loss of functional connectivity was found between the right cerebellar region and the supratentorial regulatory language areas. Also, the connectivity between the interhemispheric Broca regions and modulatory control dorsolateral prefrontal region was found to be decreased. This disruption of normal modulatory control and automation function by the cerebellum may underlie the abnormal language function in children with ASD-LI.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Elsevier
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/3.0/
dc.subject
Autism spectrum disorders
en_US
dc.subject
Cerebellum
en_US
dc.subject
Language function
en_US
dc.subject
Resting state fMRI
en_US
dc.title
Altered functional connectivity of the language network in ASD: Role of classical language areas and cerebellum
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported
dc.date.published
2014-01-30
ethz.journal.title
NeuroImage: Clinical
ethz.journal.volume
4
en_US
ethz.pages.start
374
en_US
ethz.pages.end
382
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
007621316
ethz.publication.place
Amsterdam
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02070 - Dep. Gesundheitswiss. und Technologie / Dep. of Health Sciences and Technology::02535 - Institut für Bewegungswiss. und Sport / Institut of Human Movement Sc. and Sport::03963 - Wenderoth, Nicole / Wenderoth, Nicole
ethz.date.deposited
2017-06-11T14:49:34Z
ethz.source
ECIT
ethz.identifier.importid
imp593652b2c17e329962
ethz.ecitpid
pub:148922
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-13T03:36:40Z
ethz.rosetta.lastUpdated
2019-07-01T14:13:12Z
ethz.rosetta.versionExported
true
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