Electrostatic transition state stabilization rather than reactant destabilization provides the chemical basis for efficient chorismate mutase catalysis

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Author
Burschowsky, Daniel
van Eerde, André
Ökvist, Mats
Kienhöfer, Alexander
Kast, Peter
Hilvert, Donald
Krengel, Ute
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Date
2014-12
Type
  • Journal Article
Publication status
published
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Journal / series
Proceedings of the National Academy of Sciences of the United States of America: PNAS
Volume
111(49)
Pages / Article No.
17516 - 17521
Subject
Pericyclic reaction; Catalysis; Enzyme mechanism; Near attack; Conformation; X-ray crystal structures; Escherichia-coli mutase; Enzyme catalysis; Bacillus-subtilis; Active-site; Macromolecular crystallography; Claisen rearrangement; Prephenate reaction; Antibody catalysis; Protein-structure; Mechanism
Organisational unit
08816 - Kast, Peter (Tit.-Prof.)  
03492 - Hilvert, Donald / Hilvert, Donald  
Notes
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Citations
Cited 13 times in Web of Science
ETH Bibliography
yes
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