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dc.contributor.author
Vossel, Simone
dc.contributor.author
Bauer, Markus
dc.contributor.author
Mathys, Christoph
dc.contributor.author
Adams, Rick A.
dc.contributor.author
Dolan, Raymond J.
dc.contributor.author
Stephan, Klaas
dc.contributor.author
Friston, Karl J.
dc.date.accessioned
2019-12-16T16:10:41Z
dc.date.available
2017-06-11T14:51:23Z
dc.date.available
2019-12-16T16:10:41Z
dc.date.issued
2014-11-19
dc.identifier.issn
0270-6474
dc.identifier.issn
1529-2401
dc.identifier.other
10.1523/JNEUROSCI.0091-14.2014
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/94859
dc.identifier.doi
10.3929/ethz-b-000094859
dc.description.abstract
The exact mechanisms whereby the cholinergic neurotransmitter system contributes to attentional processing remain poorly understood. Here, we applied computational modeling to psychophysical data (obtained from a spatial attention task) under a psychopharmacological challenge with the cholinesterase inhibitor galantamine (Reminyl). This allowed us to characterize the cholinergic modulation of selective attention formally, in terms of hierarchical Bayesian inference. In a placebo-controlled, within-subject, crossover design, 16 healthy human subjects performed a modified version of Posner's location-cueing task in which the proportion of validly and invalidly cued targets (percentage of cue validity, % CV) changed over time. Saccadic response speeds were used to estimate the parameters of a hierarchical Bayesian model to test whether cholinergic stimulation affected the trial-wise updating of probabilistic beliefs that underlie the allocation of attention or whether galantamine changed the mapping from those beliefs to subsequent eye movements. Behaviorally, galantamine led to a greater influence of probabilistic context (% CV) on response speed than placebo. Crucially, computational modeling suggested this effect was due to an increase in the rate of belief updating about cue validity (as opposed to the increased sensitivity of behavioral responses to those beliefs). We discuss these findings with respect to cholinergic effects on hierarchical cortical processing and in relation to the encoding of expected uncertainty or precision.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Society for Neuroscience
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.subject
acetylcholine
en_US
dc.subject
Bayesian inference
en_US
dc.subject
saccades
en_US
dc.subject
Spatial attention
en_US
dc.title
Cholinergic Stimulation Enhances Bayesian Belief Updating in the Deployment of Spatial Attention
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
The Journal of Neuroscience
ethz.journal.volume
34
en_US
ethz.journal.issue
47
en_US
ethz.journal.abbreviated
JNeurosci
ethz.pages.start
15735
en_US
ethz.pages.end
15742
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
000017864
ethz.publication.place
Washington, DC
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02631 - Institut für Biomedizinische Technik / Institute for Biomedical Engineering::03955 - Stephan, Klaas E. / Stephan, Klaas E.
ethz.date.deposited
2017-06-11T14:52:07Z
ethz.source
ECIT
ethz.identifier.importid
imp593652b393b5779398
ethz.ecitpid
pub:148970
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-15T10:40:08Z
ethz.rosetta.lastUpdated
2024-02-02T10:02:23Z
ethz.rosetta.versionExported
true
ethz.COinS
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