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dc.contributor.author
Parise, Francesca
dc.contributor.author
Valcher, Maria E.
dc.contributor.author
Lygeros, John
dc.date.accessioned
2020-10-01T08:00:34Z
dc.date.available
2017-06-11T14:54:12Z
dc.date.available
2020-10-01T08:00:34Z
dc.date.issued
2014
dc.identifier.isbn
978-1-4799-7746-8
en_US
dc.identifier.isbn
978-1-4673-6090-6
en_US
dc.identifier.isbn
978-1-4799-7745-1
en_US
dc.identifier.other
10.1109/CDC.2014.7040107
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/95002
dc.description.abstract
In this paper we investigate the reachable set of a standard stochastic model of controlled gene expression. Specifically, we explore what values of the protein mean and variance are achievable using the available external input, that is, the mRNA production rate. We proceed by constructing invariant sets in two-dimensional projections of the state space. We then use these sets to construct an outer approximation of the reachable region for the protein mean and variance. This can be computed solving a one-dimensional optimization problem and is tight enough to show that it is not possible, using such control input, to arbitrarily reduce the variance while maintaining a high mean. The lower bound on the variance derived with our approach turns out to be much higher than the one available in the literature for the case when both the mRNA production and degradation rate are controlled.
en_US
dc.language.iso
en
en_US
dc.publisher
IEEE
en_US
dc.title
On the reachable set of the controlled gene expression system
en_US
dc.type
Conference Paper
dc.date.published
2015-02-12
ethz.book.title
2014 IEEE 53rd Annual Conference on Decision and Control (CDC 2014)
en_US
ethz.pages.start
4597
en_US
ethz.pages.end
4604
en_US
ethz.event
53rd IEEE Annual Conference on Decision and Control (CDC 2014)
en_US
ethz.event.location
Los Angeles, CA, USA
en_US
ethz.event.date
December 15-17, 2014
en_US
ethz.publication.place
Piscataway, NJ
en_US
ethz.publication.status
published
en_US
ethz.leitzahl
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02650 - Institut für Automatik / Automatic Control Laboratory::03751 - Lygeros, John / Lygeros, John
en_US
ethz.leitzahl.certified
ETH Zürich::00002 - ETH Zürich::00012 - Lehre und Forschung::00007 - Departemente::02140 - Dep. Inf.technologie und Elektrotechnik / Dep. of Inform.Technol. Electrical Eng.::02650 - Institut für Automatik / Automatic Control Laboratory::03751 - Lygeros, John / Lygeros, John
ethz.date.deposited
2017-06-11T14:54:32Z
ethz.source
ECIT
ethz.identifier.importid
imp593652b678b9f86714
ethz.ecitpid
pub:149139
ethz.eth
yes
en_US
ethz.availability
Metadata only
en_US
ethz.rosetta.installDate
2017-07-20T18:58:30Z
ethz.rosetta.lastUpdated
2021-02-15T17:42:24Z
ethz.rosetta.versionExported
true
ethz.COinS
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