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dc.contributor.author
Martinez-Lozano Sinues, Pablo
dc.contributor.author
Tarokh, Leila
dc.contributor.author
Li, Xue
dc.contributor.author
Kohler, Malcolm
dc.contributor.author
Brown, Steven A.
dc.contributor.author
Zenobi, Renato
dc.contributor.author
Dallmann, Robert
dc.date.accessioned
2018-10-11T08:59:52Z
dc.date.available
2017-06-11T15:22:32Z
dc.date.available
2018-10-11T08:59:52Z
dc.date.issued
2014-12-29
dc.identifier.issn
1932-6203
dc.identifier.other
10.1371/journal.pone.0114422
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/96138
dc.identifier.doi
10.3929/ethz-b-000096138
dc.description.abstract
Circadian clocks play a significant role in the correct timing of physiological metabolism, and clock disruption might lead to pathological changes of metabolism. One interesting method to assess the current state of metabolism is metabolomics. Metabolomics tries to capture the entirety of small molecules, i.e. the building blocks of metabolism, in a given matrix, such as blood, saliva or urine. Using mass spectrometric approaches we and others have shown that a significant portion of the human metabolome in saliva and blood exhibits circadian modulation; independent of food intake or sleep/wake rhythms. Recent advances in mass spectrometry techniques have introduced completely non-invasive breathprinting; a method to instantaneously assess small metabolites in human breath. In this proof-of-principle study, we extend these findings about the impact of circadian clocks on metabolomics to exhaled breath. As previously established, our method allows for real-time analysis of a rich matrix during frequent non-invasive sampling. We sampled the breath of three healthy, non-smoking human volunteers in hourly intervals for 24 hours during total sleep deprivation, and found 111 features in the breath of all individuals, 36–49% of which showed significant circadian variation in at least one individual. Our data suggest that real-time mass spectrometric "breathprinting" has high potential to become a useful tool to understand circadian metabolism, and develop new biomarkers to easily and in real-time assess circadian clock phase and function in experimental and clinical settings.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Circadian Variation of the Human Metabolome Captured by Real-Time Breath Analysis
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS ONE
ethz.journal.volume
9
en_US
ethz.journal.issue
12
en_US
ethz.journal.abbreviated
PLoS ONE
ethz.pages.start
e114422
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.scopus
ethz.identifier.nebis
006206116
ethz.publication.place
San Francisco, CA, USA
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T15:23:02Z
ethz.source
ECIT
ethz.identifier.importid
imp593652cb7a5c315681
ethz.ecitpid
pub:150728
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-20T16:09:19Z
ethz.rosetta.lastUpdated
2018-10-11T09:00:04Z
ethz.rosetta.versionExported
true
ethz.COinS
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