Obien, Marie E.J.
Bakkum, Douglas J.
- Journal Article
Rights / licenseCreative Commons Attribution 4.0 International
Microelectrode arrays and microprobes have been widely utilized to measure neuronal activity, both in vitro and in vivo. The key advantage is the capability to record and stimulate neurons at multiple sites simultaneously. However, unlike the single-cell or single-channel resolution of intracellular recording, microelectrodes detect signals from all possible sources around every sensor. Here, we review the current understanding of microelectrode signals and the techniques for analyzing them. We introduce the ongoing advancements in microelectrode technology, with focus on achieving higher resolution and quality of recordings by means of monolithic integration with on-chip circuitry. We show how recent advanced microelectrode array measurement methods facilitate the understanding of single neurons as well as network function Show more
Journal / seriesFrontiers in Neuroscience
Pages / Article No.
PublisherFrontiers Research Foundation
SubjectMicroelectrode array; Neuronal function; Extracellular recording; Stimulation; CMOS; Multielectrode array; Neuron-electrode interface; Multi-scale modeling
Organisational unit03684 - Hierlemann, Andreas / Hierlemann, Andreas
132245 - Network dynamics underlying learning in embodied cortical brain cells grown over an 11,011-electrode CMOS circuit (SNF)
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