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dc.contributor.author
Zechner, Christoph
dc.contributor.author
Koeppl, Heinz
dc.date.accessioned
2018-12-13T13:59:16Z
dc.date.available
2017-06-11T16:08:46Z
dc.date.available
2018-12-13T13:59:16Z
dc.date.issued
2014-12-04
dc.identifier.issn
1553-734X
dc.identifier.issn
1553-7358
dc.identifier.other
10.1371/journal.pcbi.1003942
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/98147
dc.identifier.doi
10.3929/ethz-b-000098147
dc.description.abstract
The dynamics of stochastic reaction networks within cells are inevitably modulated by factors considered extrinsic to the network such as, for instance, the fluctuations in ribosome copy numbers for a gene regulatory network. While several recent studies demonstrate the importance of accounting for such extrinsic components, the resulting models are typically hard to analyze. In this work we develop a general mathematical framework that allows to uncouple the network from its dynamic environment by incorporating only the environment's effect onto the network into a new model. More technically, we show how such fluctuating extrinsic components (e.g., chemical species) can be marginalized in order to obtain this decoupled model. We derive its corresponding process- and master equations and show how stochastic simulations can be performed. Using several case studies, we demonstrate the significance of the approach.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Public Library of Science
en_US
dc.rights.uri
http://creativecommons.org/licenses/by/4.0/
dc.title
Uncoupled Analysis of Stochastic Reaction Networks in Fluctuating Environments
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution 4.0 International
ethz.journal.title
PLoS Computational Biology
ethz.journal.volume
10
en_US
ethz.journal.issue
12
en_US
ethz.journal.abbreviated
PLOS comput. biol.
ethz.pages.start
e1003942
en_US
ethz.size
9 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
005410277
ethz.publication.place
San Francisco, CA, USA
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T16:08:52Z
ethz.source
ECIT
ethz.identifier.importid
imp593652ee6e17c57551
ethz.ecitpid
pub:153452
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-14T18:30:56Z
ethz.rosetta.lastUpdated
2018-12-13T13:59:20Z
ethz.rosetta.exportRequired
true
ethz.rosetta.versionExported
true
ethz.COinS
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