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dc.contributor.author
Hauri, Simon
dc.contributor.author
Wepf, Alexander
dc.contributor.author
Drogen, Audrey van
dc.contributor.author
Varjosalo, Markku
dc.contributor.author
Tapon, Nic
dc.contributor.author
Aebersold, Ruedi
dc.contributor.author
Gstaiger, Matthias
dc.date.accessioned
2018-06-07T12:31:42Z
dc.date.available
2017-06-11T16:31:20Z
dc.date.available
2018-06-07T12:31:42Z
dc.date.issued
2013-01
dc.identifier.other
10.1002/msb.201304750
en_US
dc.identifier.uri
http://hdl.handle.net/20.500.11850/98927
dc.identifier.doi
10.3929/ethz-b-000098927
dc.description.abstract
Tissue homeostasis is controlled by signaling systems that coordinate cell proliferation, cell growth and cell shape upon changes in the cellular environment. Deregulation of these processes is associated with human cancer and can occur at multiple levels of the underlying signaling systems. To gain an integrated view on signaling modules controlling tissue growth, we analyzed the interaction proteome of the human Hippo pathway, an established growth regulatory signaling system. The resulting high‐resolution network model of 480 protein‐protein interactions among 270 network components suggests participation of Hippo pathway components in three distinct modules that all converge on the transcriptional co‐activator YAP1. One of the modules corresponds to the canonical Hippo kinase cassette whereas the other two both contain Hippo components in complexes with cell polarity proteins. Quantitative proteomic data suggests that complex formation with cell polarity proteins is dynamic and depends on the integrity of cell‐cell contacts. Collectively, our systematic analysis greatly enhances our insights into the biochemical landscape underlying human Hippo signaling and emphasizes multifaceted roles of cell polarity complexes in Hippo‐mediated tissue growth control.
en_US
dc.format
application/pdf
en_US
dc.language.iso
en
en_US
dc.publisher
Nature Publ. Group
en_US
dc.rights.uri
http://creativecommons.org/licenses/by-nc-sa/3.0/
dc.subject
AP-MS
en_US
dc.subject
Cell polarity
en_US
dc.subject
Hippo signaling
en_US
dc.subject
Modularity
en_US
dc.subject
Protein complex analysis
en_US
dc.title
Interaction proteome of human Hippo signaling: modular control of the co-activator YAP1
en_US
dc.type
Journal Article
dc.rights.license
Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported
dc.date.published
2013-12-20
ethz.journal.title
Molecular Systems Biology
ethz.journal.volume
9
en_US
ethz.journal.issue
1
en_US
ethz.pages.start
713
en_US
ethz.size
16 p.
en_US
ethz.version.deposit
publishedVersion
en_US
ethz.identifier.wos
ethz.identifier.nebis
004931271
ethz.publication.place
Oxford
en_US
ethz.publication.status
published
en_US
ethz.date.deposited
2017-06-11T16:32:10Z
ethz.source
ECIT
ethz.identifier.importid
imp593652ff48e2480018
ethz.ecitpid
pub:154724
ethz.eth
yes
en_US
ethz.availability
Open access
en_US
ethz.rosetta.installDate
2017-07-12T19:57:14Z
ethz.rosetta.lastUpdated
2018-11-07T11:29:22Z
ethz.rosetta.versionExported
true
ethz.COinS
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