A role for the cortex in sleep-wake regulation
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Date
2021-09
Publication Type
Journal Article
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yes
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Abstract
Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.
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published
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Journal / series
Volume
24
Pages / Article No.
1210 - 1215
Publisher
Nature