Journal: Journal of the Royal Society. Interface

Abbreviation

J. R. Soc. Interface

Publisher

Royal Society

Journal Volumes

ISSN

1742-5689
1742-5662

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Publications 1 - 10 of 105
  • The optimal deployment of synergistic antibiotics
    Item type: Journal Article
    Pena-Miller, Rafael; Lähnemann, David; Schulenburg, Hinrich; et al. (2012)
    Journal of the Royal Society. Interface
  • Reconstructing dynamic molecular states from single-cell time series
    Item type: Journal Article
    Huang, Lirong; Paulevé, Loïc; Zechner, Christoph; et al. (2016)
    Journal of the Royal Society. Interface
  • Frequency response of lift control in Drosophila
    Item type: Journal Article
    Graetzel, Chauncey F.; Nelson, Bradley J.; Fry, Steven N. (2010)
    Journal of the Royal Society. Interface
  • The digital traces of bubbles
    Item type: Journal Article
    Garcia, David; Tessone, Claudio J.; Mavrodiev, Pavlin; et al. (2014)
    Journal of the Royal Society. Interface
  • Fluid–particle dynamics in canalithiasis
    Item type: Journal Article
    Obrist, Dominik; Hegemann, Stefan (2008)
    Journal of the Royal Society. Interface
  • An efficient and unbiased method for sensitivity analysis of stochastic reaction networks
    Item type: Journal Article
    Gupta, Ankit; Khammash, Mustafa Hani (2014)
    Journal of the Royal Society. Interface
  • Orientation and size-dependent mechanical modulation within individual secondary osteons in cortical bone tissue
    Item type: Journal Article
    Carnelli, Davide; Vena, Pasquale; Dao, Ming; et al. (2013)
    Journal of the Royal Society. Interface
  • Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype
    Item type: Journal Article
    Boareto, Marcelo; Jolly, Mohit K.; Goldman, Aaron; et al. (2016)
    Journal of the Royal Society. Interface
    Metastasis can involve repeated cycles of epithelial-to-mesenchymal transition (EMT) and its reverse mesenchymal-to-epithelial transition. Cells can also undergo partial transitions to attain a hybrid epithelial/mesenchymal (E/M) phenotype that allows the migration of adhering cells to form a cluster of circulating tumour cells. These clusters can be apoptosis-resistant and possess an increased metastatic propensity as compared to the cells that undergo a complete EMT (mesenchymal cells). Hence, identifying the key players that can regulate the formation and maintenance of such clusters may inform anti-metastasis strategies. Here, we devise a mechanism-based theoretical model that links cell–cell communication via Notch-Delta-Jagged signalling with the regulation of EMT. We demonstrate that while both Notch-Delta and Notch-Jagged signalling can induce EMT in a population of cells, only Jagged-dominated Notch signalling, but not Delta-dominated signalling, can lead to the formation of clusters containing hybrid E/M cells. Our results offer possible mechanistic insights into the role of Jagged in tumour progression, and offer a framework to investigate the effects of other microenvironmental signals during metastasis.
  • Impacts of feeding less food-competing feedstuffs to livestock on global food system sustainability
    Item type: Journal Article
    Schader, Christian; Müller, Adrian; Scialabba, Nadia E.; et al. (2015)
    Journal of the Royal Society. Interface
    Increasing efficiency in livestock production and reducing the share of animal products in human consumption are two strategies to curb the adverse environmental impacts of the livestock sector. Here, we explore the room for sustainable livestock production by modelling the impacts and constraints of a third strategy in which livestock feed components that compete with direct human food crop production are reduced. Thus, in the outmost scenario, animals are fed only from grassland and by-products from food production. We show that this strategy could provide sufficient food (equal amounts of human-digestible energy and a similar protein/calorie ratio as in the reference scenario for 2050) and reduce environmental impacts compared with the reference scenario (in the most extreme case of zero human-edible concentrate feed: greenhouse gas emissions −18%; arable land occupation −26%, N-surplus −46%; P-surplus −40%; non-renewable energy use −36%, pesticide use intensity −22%, freshwater use −21%, soil erosion potential −12%). These results occur despite the fact that environmental efficiency of livestock production is reduced compared with the reference scenario, which is the consequence of the grassland-based feed for ruminants and the less optimal feeding rations based on by-products for non-ruminants. This apparent contradiction results from considerable reductions of animal products in human diets (protein intake per capita from livestock products reduced by 71%). We show that such a strategy focusing on feed components which do not compete with direct human food consumption offers a viable complement to strategies focusing on increased efficiency in production or reduced shares of animal products in consumption.
  • Brilliant cresyl blue enhanced optoacoustic imaging enables non-destructive imaging of mammalian ovarian follicles for artificial reproduction: Brilliant cresyl blue enhanced optoacoustic imaging enables non-destructive imaging of mammalian ovarian follicles for artificial reproduction
    Item type: Journal Article
    Dutta, Rahul; Mandal, Subhamoy; Lin, Hsiao-Chun A.; et al. (2020)
    Journal of the Royal Society. Interface
    In the field of reproductive biology, there is a strong need for a suitable tool capable of non-destructive evaluation of oocyte viability and function. We studied the application of brilliant cresyl blue (BCB) as an intra-vital exogenous contrast agent using multispectral optoacoustic tomography (MSOT) for visualization of porcine ovarian follicles. The technique provided excellent molecular sensitivity, enabling the selection of competent oocytes without disrupting the follicles. We further conducted in vitro embryo culture, molecular analysis (real-time and reverse transcriptase polymerase chain reaction) and DNA fragmentation analysis to comprehensively establish the safety of BCB-enhanced MSOT imaging in monitoring oocyte viability. Overall, the experimental results suggest that the method offers a significant advance in the use of contrast agents and molecular imaging for reproductive studies. Our technique improves the accurate prediction of ovarian reserve significantly and, once standardized for in vivo imaging, could provide an effective tool for clinical infertility management.
Publications 1 - 10 of 105