Plasticity and heterogeneity of thermogenic adipose tissue
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Date
2021-06-22
Publication Type
Review Article
ETH Bibliography
yes
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Abstract
The perception of adipose tissue, both in the scientific community and in the general population, has changed dramatically in the past 20 years. While adipose tissue was thought for a long time to be a rather simple lipid storage entity, it is now recognized as a highly heterogeneous organ and a critical regulator of systemic metabolism, composed of many different subtypes of cells, with important endocrine functions. Additionally, adipose tissue is nowadays recognized to contribute to energy turnover, due to the presence of specialized thermogenic adipocytes, which can be found in many adipose depots. This review discusses the unprecedented insights that we have gained into the heterogeneity of thermogenic adipocytes and their respective precursors due to the technical developments in single-cell and nucleus technologies. These methodological advances have increased our understanding of how adipose tissue catabolic function is influenced by developmental and intercellular communication events.
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published
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Journal / series
Volume
3
Pages / Article No.
751 - 761
Publisher
Nature
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Date collected
Date created
Subject
Cardiovascular biology; Cell signalling; Fat metabolism
Organisational unit
03819 - Wolfrum, Christian (ehemalig) / Wolfrum, Christian (former)
Notes
Funding
185011 - Adipose tissue heterogeneity and metabolic control (SNF)