Journal: Clinical Neuroradiology

Abbreviation

Clin Neuroradiol

Publisher

Springer

Journal Volumes

ISSN

1869-1447
1869-1439

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Filters

2019 - 20202
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Publications 1 - 2 of 2
  • Optimized Combination of b‑values for IVIM Perfusion Imaging in Acute Ischemic Stroke Patients
    Item type: Journal Article
    Zhu, Guangming; Heit, Jeremy J.; Martin, Blake W.; et al. (2020)
    Clinical Neuroradiology
    Purpose: To determine the optimal combination of low b‑values to generate perfusion information from intravoxel incoherent motion (IVIM) in patients with acute ischemic stroke (AIS) considering the time constraints for these patients. Methods: A retrospective cohort study of AIS patients with IVIM MRI was performed. A two-step voxel-by-voxel postprocessing was used to derive IVIM perfusion fraction maps with different combinations of b values. Signal values within regions of ischemic core, non-infarcted ischemic hemisphere, and contralateral hemisphere were measured on IVIM (f, D*, fD*, D) parameter maps. Bland-Altman analysis and the Dice similarity coefficient were used to determine quantitative and spatial agreements between the reference standard IVIM (IVIM with 6 b values of 0, 50, 100, 150, 200, 1000 s/mm2) and other combinations of b values. Significance level was set at p < 0.05. Results: There were 58 patients (36 males, 61.3%; mean age 70.2 ± 13.4 years) included. Considering all IVIM parameters, the combination of b values of 0, 50, 200, 1000 was the most consistent with our reference standard on Bland-Altman analysis. The best voxel-based overlaps of ischemic regions were on IVIM D, while there were good voxel-based overlaps on IVIM f. Conclusion: The IVIM with these four b values collects diffusion and perfusion information from a single short MRI sequence, which may have important implications for the imaging of AIS patients. © 2019, Springer-Verlag GmbH Germany, part of Springer Nature.
  • Investigation of Neurodegenerative Processes in Amyotrophic Lateral Sclerosis Using White Matter Fiber Density
    Item type: Journal Article
    Stämpfli, Philipp; Sommer, Stefan; Czell, David; et al. (2019)
    Clinical Neuroradiology
Publications 1 - 2 of 2