A simple quantitative model of neuromodulation, Part I: Ion flow through neural ion channels
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2024-01
Publication Type
Journal Article
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yes
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Abstract
We develop a simple model of ionic current through neuronal membranes as a function of membrane potential and extracellular ion concentration. The model combines a simplified Poisson–Nernst–Planck (PNP) model of ion transport through individual ion channels with channel activation functions calibrated from ad hoc in-house experimental data. The simplified PNP model is validated against bacterial gramicidin A ion channel data. The calibrated model accounts for the transport of calcium, sodium, potassium, and chloride and exhibits remarkable agreement with the experimentally measured current–voltage curves for the differentiated human neural cells. All relevant data and code related to the ion flow models are available at Werneck et al. (2023).
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published
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182
Pages / Article No.
105457
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Elsevier
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Subject
Ultrasound neuromodulation; Multiscale modeling; Electro-chemical coupling; Neuron computational models