Journal: Brain, Behavior, and Immunity

Abbreviation

Brain Behav. Immun.

Publisher

Elsevier

Journal Volumes

ISSN

0889-1591
1090-2139

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Publications 1 - 10 of 40
  • Delayed response and lack of habituation in plasma interleukin-6 to acute mental stress in men
    Item type: Journal Article
    von Känel, Roland; Kudielka, Brigitte M.; Preckel, Daniel; et al. (2006)
    Brain, Behavior, and Immunity
  • Fluoxetine treatment affects the inflammatory response and microglial function according to the quality of the living environment
    Item type: Journal Article
    Alboni, Silvia; Poggini, Silvia; Garofalo, Stefano; et al. (2016)
    Brain, Behavior, and Immunity
  • Ontogeny and plasticity of resilience and susceptibility in a mouse model of maternal immune activation
    Item type: Journal Article
    Schaer, Ron; Wenger, Nicole; Herrero, Felisa; et al. (2025)
    Brain, Behavior, and Immunity
    Maternal immune activation (MIA) during pregnancy results in variable neurodevelopmental and behavioral outcomes in both humans and animal models. In a mouse model of MIA using prenatal poly(I:C) administration, we recently identified subgroups of MIA-exposed offspring with distinct behavioral and transcriptional profiles even under genetic homogeneity. Here, we used the same model to explore whether the expression of resilient and susceptible phenotypes after MIA represents stable traits or whether they exhibit plasticity throughout adolescent maturation. Conducting longitudinal testing in a first cohort, we revealed that MIA offspring can be stratified into subgroups with distinct behavioral profiles at juvenile age. This early divergence was sex-dependent and predictive of different behavioral outcomes at adult age. In a second cohort, we examined the effects of repeated social intervention during peri-adolescence on brain and behavioral trajectories. In male MIA offspring displaying juvenile deficits in sociability and hyperactivity, the intervention did not alleviate adult deficits in sociability or temporal order memory but prevented the adult emergence of prepulse inhibition impairments. Conversely, in female MIA offspring with juvenile social deficits, the intervention improved adult deficits in sociability and temporal order memory, but it failed to normalize adult impairments in prepulse inhibition. These sex-specific behavioral outcomes were paralleled by subgroup-specific changes in oxytocinergic and dopaminergic markers in cortical and subcortical brain regions. Together, our findings indicate that MIA-exposed offspring can be stratified into distinct subgroups early in life, with subsequent risk and resilience trajectories varying by sex. Moreover, our data identify a window of plasticity during which targeted interventions can modulate abnormal maturational trajectories, ultimately mitigating the long-term effects of MIA in a sex-dependent manner.
  • Physical defeat reduces the sensitivity of murine splenocytes to the suppressive effects of corticosterone
    Item type: Journal Article
    Bailey, Michael T.; Avitsur, Ronit; Engler, Harald; et al. (2004)
    Brain, Behavior, and Immunity
    Social disruption (SDR) in male mice reduces the sensitivity of their splenocytes to the actions of glucocorticoids. To determine whether physical defeat is necessary for the development of this reduced sensitivity, a modification of the SDR paradigm was employed in which mice were exposed to fighting conspecifics in the presence or absence of physical contact. This was accomplished by dividing a cage of 5 resident male C57BL/6 mice in half with a wire mesh partition so that 2 of the mice in the cage (SDR Physical Contact mice) fought and were defeated by an aggressive male C57BL/6 intruder that was placed into the cage for 2 h for up to 6 days, while the remaining 3 resident mice (SDR Sensory Contact mice) were on the opposite side of the partition and thus prevented from physically interacting with the intruder. Although both the SDR Physical Contact and the SDR Sensory Contact mice had significantly elevated corticosterone levels and displayed submissive postures toward the intruder, only the SDR Physical Contact animals developed functional glucocorticoid resistance. The viability of LPS-stimulated splenocytes cultured from the SDR Physical Contact mice was not affected by pharmacological doses of corticosterone, whereas splenocyte viability was significantly reduced by corticosterone in cultured cells from SDR Sensory Contact and control mice. This study indicates that exposure to a stressful environment in the absence of physical attack does not reduce the sensitivity of murine splenocytes to the suppressive effects of corticosterone.
  • Visceral pain and public speaking stress
    Item type: Journal Article
    Lucas, A.; Holtmann, G.; Gerken, G.; et al. (2006)
    Brain, Behavior, and Immunity
  • Stimulation of β2-adrenergic receptors inhibits calcineurin activity in CD4+ T cells via PKA–AKAP interaction
    Item type: Journal Article
    Riether, Carsten; Kavelaars, Annemieke; Wirth, Timo; et al. (2011)
    Brain, Behavior, and Immunity
  • Assessment of neurobehavioural traits under gnotobiotic conditions: an approach for multiple analyses in the same mouse
    Item type: Journal Article
    Rutsch , Andrina; Iachizzi , Monica; Kirundi , Jorum; et al. (2025)
    Brain, Behavior, and Immunity
    The gut-microbiota-brain axis influences neuroinflammation, neural development and behaviour such as sociability, memory and anxiety. To study these traits in vivo, especially during development or disease, it is crucial to analyse them over time and with multiple analyses in the same animal. With a growing understanding of the role of specific bacteria in neurodegenerative disease and behaviour, the demand for gnotobiotic mouse models has increased. However, maintaining stable hygienic conditions during behavioural testing is challenging, as exposure to conventional environments can alter the hygienic status of mice and affect behaviour. We established protocols to perform behavioural tests assessing memory, anxiety, exploration, learning and recognition under axenic conditions using flexible film isolators. Our study compared the behaviour of germ-free mice with mice carrying a defined minimal or moderately diverse microbiota. The results showed no effect of the microbiota on short- and long-term memory or novel object recognition. However, we showed that mice colonised with defined moderately diverse commensal bacteria exhibited more anxiety-like behaviour than germ-free mice. In addition, we showed that microbiota complexity is important, as only mice colonised with moderately diverse microbiota exhibited anxiety-like behaviour, allowing us to disentangle the contribution of specific microbial species or community interactions to this phenotype. This phenotype associated with differences in hippocampal and serum metabolic profiles between colonised and germ-free mice. We propose a novel approach to study rodent behaviour at different physiological and pathological stages in their life without compromising hygiene, thus promoting the refinement and reduction of mice used in experiments.
  • Prenatal versus postnatal maternal factors in the development of infection-induced working memory impairments in mice
    Item type: Journal Article
    Richetto, Juliet; Calabrese, Francesca; Meyer, Urs; et al. (2013)
    Brain, Behavior, and Immunity
  • Inhibitory effects of lipopolysaccharide on hypothalamic nuclei implicated in the control of food intake
    Item type: Journal Article
    Becskei, Csilla; Riediger, Thomas; Hernadfalvy, Noémi; et al. (2008)
    Brain, Behavior, and Immunity
  • CD40-TNF activation in mice induces extended sickness behavior syndrome co-incident with but not dependent on activation of the kynurenine pathway
    Item type: Journal Article
    Cathomas, Flurin; Fuertig, Rene; Sigrist, Hannes; et al. (2015)
    Brain, Behavior, and Immunity
Publications 1 - 10 of 40