An open-source computational and data resource to analyze digital maps of immunopeptidomes
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Date
2015-07
Publication Type
Journal Article
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yes
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Abstract
We present a novel mass spectrometry-based high-throughput workflow and an open-source computational and data resource to reproducibly identify and quantify HLA-associated peptides. Collectively, the resources support the generation of HLA allele-specific peptide assay libraries consisting of consensus fragment ion spectra, and the analysis of quantitative digital maps of HLA peptidomes generated from a range of biological sources by SWATH mass spectrometry (MS). This study represents the first community-based effort to develop a robust platform for the reproducible and quantitative measurement of the entire repertoire of peptides presented by HLA molecules, an essential step towards the design of efficient immunotherapies.
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published
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4
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eLife Sciences Publications
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Software
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03663 - Aebersold, Rudolf (emeritus) / Aebersold, Rudolf (emeritus)