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Shock-compression-based equation of state for perfluorohexane
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2025-12-01
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Journal Article
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Abstract
Perfluorohexane is a biocompatible material that serves as a liquid core for acoustically responsive agents in biomedical applications. Despite its relatively widespread usage, there is a lack of experimental data determining its thermodynamic properties. This challenges numerical simulations to predict the acoustic response of agents developed using this material. In this study, we employ the well-established method of shock compression of materials at relatively high pressures (100–400MPa) to estimate a kinematic equation of state for perfluorohexane. We use multi-objective optimization to obtain the Noble-Abel stiffened-gas equation of state, which is suitable for hydrodynamic numerical simulations. We then apply the extrapolated equation of state to simulate shock-wave propagation within a perfluorohexane droplet showing excellent agreement with equivalent experiments. This promotes the use of numerical simulations as a valuable tool for understanding the complex acoustic interactions involved in these biomedical agents, ultimately facilitating their translation for clinical purposes.
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112 (6)