“EvoVax” – A rationally designed inactivated Salmonella Typhimurium vaccine induces strong and long-lasting immune responses in pigs
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Date
2023-08-31
Publication Type
Journal Article
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yes
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Abstract
Salmonella enterica subspecies enterica serovar Typhimurium (S.Tm) poses a considerable threat to public health due to its zoonotic potential. Human infections are mostly foodborne, and pork and pork products are ranked among the top culprits for transmission. In addition, the high percentage of antibiotic resistance, especially in monophasic S.Tm, limits treatment options when needed. Better S.Tm control would therefore be of benefit both for farm animals and for safety of the human food chain. A promising pre-harvest intervention is vaccination. In this study we tested safety and immunogenicity of an oral inactivated S.Tm vaccine, which has been recently shown to generate an “evolutionary trap” and to massively reduce S.Tm colonization and transmission in mice. We show that this vaccine is highly immunogenic and safe in post-weaning pigs and that administration of a single oral dose results in a strong and long-lasting serum IgG response. This has several advantages over existing – mainly live – vaccines against S.Tm, both in improved seroconversion and reduced risk of vaccine-strain persistence and reversion to virulence.
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Publication status
published
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Book title
Journal / series
Volume
41 (38)
Pages / Article No.
5545 - 5552
Publisher
Elsevier
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Edition / version
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Date collected
Date created
Subject
Oral vaccine; Salmonella; Evolutionary trap; Swine; EvoVax
Organisational unit
09640 - Wetter Slack, Emma / Wetter Slack, Emma
Notes
Funding
180953 - Self-assembling glycoprotein nanoparticle vaccines (SNF)
185128 - How to resolve dysbiosis: Understanding and manipulating mechanisms of T cell-microbiota crosstalk (SNF)
865730 - Systems-level novel understanding of anti-gylcan immunity (EC)
-180575 - NCCR Microbiomes SNF (SNF)
185128 - How to resolve dysbiosis: Understanding and manipulating mechanisms of T cell-microbiota crosstalk (SNF)
865730 - Systems-level novel understanding of anti-gylcan immunity (EC)
-180575 - NCCR Microbiomes SNF (SNF)
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