Cell and scaffold surface engineering to enhance cell migration and tissue regeneration
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Author / Producer
Date
2014-03
Publication Type
Review Article
ETH Bibliography
no
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Abstract
The principles of surface engineering can be applied to cells and biomaterial scaffolds in efforts to treat disease, disorder, infection and injury. Although the bodys endogenous response to some injuries is limited, cell-based approaches exploiting native physiology, namely, through the use of gene therapy or cell surface receptors hold significant promise in treating injured or diseased tissues. Shifting binding affinities of native receptors, causing expression of non-native receptors, or binding synthetic receptors onto the surfaces of cells are the techniques that increase cellular targeting, migration and engraftment. Scaffold modification techniques that increase a scaffolds bioactivity by providing signaling factors to endogenous cells can be used to elicit a desired response from an otherwise inert polymer. This review summarizes the endogenous homing and targeting response of leukocytes and stem cells to provide context for subsequent sections outlining existing ways of surface-modifying cells and biomaterials.
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Publication status
published
External links
Editor
Book title
Journal / series
Volume
2 (1)
Pages / Article No.
17 - 25
Publisher
Institution of Civil Engineers
Event
Edition / version
Methods
Software
Geographic location
Date collected
Date created
Subject
biomaterial; bone; cell–surface interaction; drug delivery; regeneration; scaffold; soft tissue; tissue engineering
Organisational unit
09862 - März, Tristan / März, Tristan