Journal: Aids Research and Human Retroviruses

Abbreviation

Publisher

Mary Ann Liebert

Journal Volumes

ISSN

0889-2229
1931-8405

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2005 - 200922010 - 20192
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Publications 1 - 4 of 4
  • The Changing Epidemiological Profile of HIV-1 Subtype B Epidemic in Ukraine
    Item type: Journal Article
    Vasylyeva, Tetyana I.; Liulchuk, Mariia; Du Plessis, Louis; et al. (2019)
    Aids Research and Human Retroviruses
    While HIV-1 subtype B has caused a large epidemic in the Western world, its transmission in Ukraine remains poorly understood. We assessed the genetic diversity of HIV-1 subtype B viruses circulating in Ukraine, characterized the transmission group structure, and estimated key evolutionary and epidemiological parameters. We analyzed 120 HIV-1 subtype B pol sequences (including 46 newly generated) sampled from patients residing in 11 regions of Ukraine between 2002 and 2017. Phylogenies were estimated using maximum likelihood and Bayesian phylogenetic methods. A Bayesian molecular clock coalescent analysis was used to estimate effective population size dynamics and date the most recent common ancestors of identified clades. A phylodynamic birth–death model was used to estimate the effective reproductive number (Re) of these clades. We identified two phylogenetically distinct predominantly Ukrainian (≥75%) clades of HIV-1 subtype B. We found no significant transmission group structure for either clade, suggesting frequent mixing among transmission groups. The estimated dates of origin of both subtype B clades were around early 1970s, similar to the introduction of HIV-1 subtype A into Ukraine. Re was estimated to be 1.42 [95% highest posterior density (HPD) 1.26–1.56] for Clade 1 and 1.69 (95% HPD 1.49–1.84) for Clade 2. Evidently, the subtype B epidemic in the country is no longer concentrated in specific geographical regions or transmission groups. The study results highlight the necessity for strengthening preventive and monitoring efforts to reduce the further spread of HIV-1 subtype B.
  • Phylogenetic analysis of known exogenous and endogenous retroviral sequences gag, pol, and env
    Item type: Other Conference Item
    Kitze, Bernd; Margadant, Daniel (2007)
    Aids Research and Human Retroviruses
  • The V1V2 Domain Preserves Envelope Functionality During Free Virus Transmission but Is Largely Dispensable for Cell-Cell Transmission
    Item type: Other Conference Item
    Brandenberg, O.F.; Rusert, P.; Magnus, C.; et al. (2013)
    Aids Research and Human Retroviruses
  • HIV Type 2 Dynamics
    Item type: Other Journal Item
    Brandin, Eleonor; Broström, Christina; Gille, Elena; et al. (2005)
    Aids Research and Human Retroviruses
Publications 1 - 4 of 4