Symbiotic electroneural and musculoskeletal framework to encode proprioception via neurostimulation: ProprioStim
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Date
2023-03-17
Publication Type
Journal Article
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yes
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Abstract
Peripheral nerve stimulation in amputees achieved the restoration of touch, but not proprioception, which is critical in locomotion. A plausible reason is the lack of means to artificially replicate the complex activity of proprioceptors. To uncover this, we coupled neuromuscular models from ten subjects and nerve histologies from two implanted amputees to develop ProprioStim: a framework to encode proprioception by electrical evoking neural activity in close agreement with natural proprioceptive activity. We demonstrated its feasibility through non-invasive stimulation on seven healthy subjects comparing it with standard linear charge encoding. Results showed that ProprioStim multichannel stimulation was felt more natural, and hold promises for increasing accuracy in knee angle tracking, especially in future implantable solutions. Additionally, we quantified the importance of realistic 3D-nerve models against extruded models previously adopted for further design and validation of novel neurostimulation encoding strategies. ProprioStim provides clear guidelines for the development of neurostimulation policies restoring natural proprioception.
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published
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26 (3)
Pages / Article No.
106248
Publisher
Elsevier
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Organisational unit
09632 - Raspopovic, Stanisa (ehemalig) / Raspopovic, Stanisa (former)
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Funding
759998 - Restoring natural feelings from missing or damaged peripheral nervous system by model-driven neuroprosthesis (EC)
197271 - Multimodal targeted neurotechnology for gait improvement and neuropathic pain suppression in diabetic neuropathy (MOVEIT) (SNF)
197271 - Multimodal targeted neurotechnology for gait improvement and neuropathic pain suppression in diabetic neuropathy (MOVEIT) (SNF)
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Is cited by: https://doi.org/10.3929/ethz-b-000712723