Neuronal population representation of human emotional memory
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Date
2024-04-23
Publication Type
Journal Article
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yes
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Abstract
Understanding how emotional processing modulates learning and memory is crucial for the treatment of neuropsychiatric disorders characterized by emotional memory dysfunction. We investigate how human medial temporal lobe (MTL) neurons support emotional memory by recording spiking activity from the hippocampus, amygdala, and entorhinal cortex during encoding and recognition sessions of an emotional memory task in patients with pharmaco-resistant epilepsy. Our findings reveal distinct representations for both remembered compared to forgotten and emotional compared to neutral scenes in single units and MTL population spiking activity. Additionally, we demonstrate that a distributed network of human MTL neurons exhibiting mixed selectivity on a single-unit level collectively processes emotion and memory as a network, with a small percentage of neurons responding conjointly to emotion and memory. Analyzing spiking activity enables a detailed understanding of the neurophysiological mechanisms underlying emotional memory and could provide insights into how emotion alters memory during healthy and maladaptive learning.
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published
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Journal / series
Volume
43 (4)
Pages / Article No.
114071
Publisher
Cell Press
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Software
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Subject
episodic memory; medial temporal lobe; hippocampus; amygdala; singleunits; demixed principal component analysis
Organisational unit
02202 - Zentrum für Neurowissenschaften / Neuroscience Center Zurich