Targeted protein degradation: from small molecules to complex organelles-a Keystone Symposia report
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Date
2022-04
Publication Type
Journal Article
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yes
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Abstract
Targeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome-lysosome pathway, must be tightly regulated to ensure proper elimination of misfolded and aggregated proteins and regulate changing protein levels during cellular differentiation, while ensuring that normal proteins remain unscathed. Protein degradation pathways have also garnered interest as a means to selectively eliminate target proteins that may be difficult to inhibit via other mechanisms. On June 7 and 8, 2021, several experts in protein degradation pathways met virtually for the Keystone eSymposium "Targeting protein degradation: from small molecules to complex organelles." The event brought together researchers working in different protein degradation pathways in an effort to begin to develop a holistic, integrated vision of protein degradation that incorporates all the major pathways to understand how changes in them can lead to disease pathology and, alternatively, how they can be leveraged for novel therapeutics.
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published
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Journal / series
Volume
1510 (1)
Pages / Article No.
79 - 99
Publisher
Wiley
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Subject
aggregation; autophagy; lysophagy; proteasome; protein degradation; ubiquitin
Organisational unit
08811 - Weber-Ban, Eilika (Tit.-Prof.)