Bird's-Eye View: Current Understanding and Future Perspectives on the Biodefluorination of Per- and Polyfluoroalkyl Substances (PFAS)
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Date
2025-09-01
Publication Type
Review Article
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yes
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Abstract
Per- and polyfluoroalkyl substances (PFAS) have been extensively used in various industrial and manufacturing processes. These compounds pose potential risks to public health and ecosystems because of their persistence, bioaccumulation potential, and toxicity. To date, great efforts have been made to investigate the biotransformation of PFAS, while little is known about their biodefluorination behavior. A comprehensive understanding of biodefluorination mechanisms can not only aid in revealing the environmental fate and effects of these fluorinated chemicals but also advance the design of alternative structures with reduced persistence and environmental impact. In this review, we (1) systematically reviewed the biodefluorination pathways and transformation products of PFAS, with particular emphasis on emerging PFAS, under both aerobic and anaerobic conditions, (2) summarized the responsible microorganisms and enzymes involved, (3) provided critical perspectives on the need to standardize the testing protocol and to generalize the biotransformation prediction approaches, and (4) highlighted the potential of benign-by-design strategies in developing degradable fluorinated alternatives.
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published
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Journal / series
Volume
28
Pages / Article No.
100356
Publisher
Elsevier
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Edition / version
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Subject
Emerging PFAS; Biodefluorination; Safe and sustainable by design chemicals; Green chemistry
Organisational unit
03850 - McNeill, Kristopher / McNeill, Kristopher